Cholesterol and coronary heart disease. A new era

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Evidence relating plasma cholesterol levels to atherosclerosis and CHD has become so strong as to leave little doubt of the etiologic connection. Mechanisms responsible for high concentrations of LDL are becoming well understood, and the LDL receptor is now recognized as the crucial element in the control of the cholesterol level. The demonstration that lowering the plasma cholesterol level will reduce the risk of CHD provides a strong impetus to intervene in the 'mass hypercholesterolemia' prevalent among Americans. Dietary modification for this purpose will likely remain the foundation of intervention, but the full impact of new drugs that will dramatically lower the plasma cholesterol level cannot be predicted with certainty at this time. The introduction of these drugs does, however, create a great urgency to determine the proper means of effectively reducing the plasma cholesterol level for the purpose of decreasing coronary risk. With little doubt, the next decade will see a massive effort to utilize these recent breakthroughs in cholesterol control for prevention of CHD.

Original languageEnglish (US)
Pages (from-to)2849-2858
Number of pages10
JournalJournal of the American Medical Association
Issue number20
Publication statusPublished - 1986


ASJC Scopus subject areas

  • Medicine(all)

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