Choline Acetyltransferase and Acetylcholinesterase: Their Role in the Causes of Myasthenia Gravis

D. R. Gentner, R. N. Rosenberg

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Choline acetyltransferase, acetylcholinesterase, and pseudocholinesterase levels were measured in needle biopsy samples of deltoid muscle from subjects with myasthenia gravis and from normal controls. Choline acetyltransferase activities were about 30% lower and acetylcholinesterase activities about 45% lower in myasthenics as compared with controls. These decreased activities, however, are not significant in the cause of the disease; it is postulated that the primary defect at the neuromuscular junction may be the presence of a false transmitter in the synaptic vesicle or defective release of the vesicle contents at the synaptic cleft.

Original languageEnglish (US)
Pages (from-to)521-525
Number of pages5
JournalArchives of neurology
Volume27
Issue number6
DOIs
StatePublished - Dec 1972

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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