Choline acetyltransferase immunoreactivity in neuritic plaques of Alzheimer brain

David M. Armstrong, Gordon Bruce, Louis B. Hersh, Robert D. Terry

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

We have observed dystrophic choline acetyltransferase (ChAT)-positive processes surrounding the amyloid core of neuritic plaques in human neocortex, amygdala and hippocampus, using a polyclonal anti-human ChAT antiserum. These data, and those from studies of the aged monkey by other investigators, provide a morphologic counterpart for the biochemical abnormality of the cholinergic system in Alzheimer's disease and senile dementia of the Alzheimer type.

Original languageEnglish (US)
Pages (from-to)229-234
Number of pages6
JournalNeuroscience Letters
Volume71
Issue number2
DOIs
StatePublished - Nov 11 1986

Fingerprint

Choline O-Acetyltransferase
Amyloid Plaques
Alzheimer Disease
Brain
Neocortex
Amygdala
Amyloid
Cholinergic Agents
Haplorhini
Immune Sera
Hippocampus
Research Personnel

Keywords

  • Alzheimer's disease
  • Choline acetyltransferase
  • Human
  • Immunocytochemistry
  • Neuritic plaque

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Choline acetyltransferase immunoreactivity in neuritic plaques of Alzheimer brain. / Armstrong, David M.; Bruce, Gordon; Hersh, Louis B.; Terry, Robert D.

In: Neuroscience Letters, Vol. 71, No. 2, 11.11.1986, p. 229-234.

Research output: Contribution to journalArticle

Armstrong, David M. ; Bruce, Gordon ; Hersh, Louis B. ; Terry, Robert D. / Choline acetyltransferase immunoreactivity in neuritic plaques of Alzheimer brain. In: Neuroscience Letters. 1986 ; Vol. 71, No. 2. pp. 229-234.
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