Choline acetyltransferase immunoreactivity in neuritic plaques of Alzheimer brain

David M. Armstrong, Gordon Bruce, Louis B. Hersh, Robert D. Terry

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

We have observed dystrophic choline acetyltransferase (ChAT)-positive processes surrounding the amyloid core of neuritic plaques in human neocortex, amygdala and hippocampus, using a polyclonal anti-human ChAT antiserum. These data, and those from studies of the aged monkey by other investigators, provide a morphologic counterpart for the biochemical abnormality of the cholinergic system in Alzheimer's disease and senile dementia of the Alzheimer type.

Original languageEnglish (US)
Pages (from-to)229-234
Number of pages6
JournalNeuroscience Letters
Volume71
Issue number2
DOIs
StatePublished - Nov 11 1986

    Fingerprint

Keywords

  • Alzheimer's disease
  • Choline acetyltransferase
  • Human
  • Immunocytochemistry
  • Neuritic plaque

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this