Choline acetyltransferase immunoreactivity in neuritic plaques of Alzheimer brain

David M. Armstrong; Gordon Bruce; Louis B. Hersh; Robert D. Terry

doi:10.1016/0304-3940(86)90564-1

Choline acetyltransferase immunoreactivity in neuritic plaques of Alzheimer brain

David M. Armstrong, Gordon Bruce, Louis B. Hersh, Robert D. Terry

Pediatrics

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Abstract

We have observed dystrophic choline acetyltransferase (ChAT)-positive processes surrounding the amyloid core of neuritic plaques in human neocortex, amygdala and hippocampus, using a polyclonal anti-human ChAT antiserum. These data, and those from studies of the aged monkey by other investigators, provide a morphologic counterpart for the biochemical abnormality of the cholinergic system in Alzheimer's disease and senile dementia of the Alzheimer type.

Original language	English (US)
Pages (from-to)	229-234
Number of pages	6
Journal	Neuroscience letters
Volume	71
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(86)90564-1
State	Published - Nov 11 1986

Keywords

Alzheimer's disease
Choline acetyltransferase
Human
Immunocytochemistry
Neuritic plaque

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(86)90564-1

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title = "Choline acetyltransferase immunoreactivity in neuritic plaques of Alzheimer brain",

abstract = "We have observed dystrophic choline acetyltransferase (ChAT)-positive processes surrounding the amyloid core of neuritic plaques in human neocortex, amygdala and hippocampus, using a polyclonal anti-human ChAT antiserum. These data, and those from studies of the aged monkey by other investigators, provide a morphologic counterpart for the biochemical abnormality of the cholinergic system in Alzheimer's disease and senile dementia of the Alzheimer type.",

keywords = "Alzheimer's disease, Choline acetyltransferase, Human, Immunocytochemistry, Neuritic plaque",

author = "Armstrong, {David M.} and Gordon Bruce and Hersh, {Louis B.} and Terry, {Robert D.}",

note = "Funding Information: Supportedin part by NIH Grants AG05893 (L.B.H.), AG05344, a grant from the McKnight Foundation.",

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AU - Armstrong, David M.

AU - Bruce, Gordon

AU - Hersh, Louis B.

AU - Terry, Robert D.

N1 - Funding Information: Supportedin part by NIH Grants AG05893 (L.B.H.), AG05344, a grant from the McKnight Foundation.

PY - 1986/11/11

Y1 - 1986/11/11

N2 - We have observed dystrophic choline acetyltransferase (ChAT)-positive processes surrounding the amyloid core of neuritic plaques in human neocortex, amygdala and hippocampus, using a polyclonal anti-human ChAT antiserum. These data, and those from studies of the aged monkey by other investigators, provide a morphologic counterpart for the biochemical abnormality of the cholinergic system in Alzheimer's disease and senile dementia of the Alzheimer type.

AB - We have observed dystrophic choline acetyltransferase (ChAT)-positive processes surrounding the amyloid core of neuritic plaques in human neocortex, amygdala and hippocampus, using a polyclonal anti-human ChAT antiserum. These data, and those from studies of the aged monkey by other investigators, provide a morphologic counterpart for the biochemical abnormality of the cholinergic system in Alzheimer's disease and senile dementia of the Alzheimer type.

KW - Alzheimer's disease

KW - Choline acetyltransferase

KW - Human

KW - Immunocytochemistry

KW - Neuritic plaque

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ER -

Choline acetyltransferase immunoreactivity in neuritic plaques of Alzheimer brain

Abstract

Keywords

ASJC Scopus subject areas

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