Chromomycin SA analogs from a marine-derived Streptomyces sp.

Youcai Hu, Ana Paula D M Espindola, Nathan A. Stewart, Shuguang Wei, Bruce A. Posner, John B. MacMillan

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Two chromomycin SA analogs, chromomycin SA 3 and chromomycin SA 2, along with deacetylchromomycin A 3 and five previously reported chromomycin analogs were isolated from a marine-derived Streptomyces sp. The structures of the new compounds were determined by spectroscopic methods including 1D and 2D NMR techniques, HRMS and chemical methods. Chromomycin SA 3 and chromomycin SA 2 are the first naturally occuring chromomycin analogs with truncated side-chains. Biological evaluation of chromomycin analogs for cytotoxicity against two non-small cell lung cancer (NSCLC) cell-lines, A549 and HCC44, demonstrated a decrease in cytotoxicity for the truncated sides chain chromomycin analogs.

Original languageEnglish (US)
Pages (from-to)5183-5189
Number of pages7
JournalBioorganic and Medicinal Chemistry
Volume19
Issue number17
DOIs
StatePublished - Sep 1 2011

Keywords

  • Anti-cancer agents
  • Aureolic acid
  • Chromomycin
  • Isolation
  • Marine actinomycetes
  • Natural products

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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