Chromomycin SA analogs from a marine-derived Streptomyces sp.

Youcai Hu, Ana Paula D M Espindola, Nathan A. Stewart, Shuguang Wei, Bruce A. Posner, John B. MacMillan

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Two chromomycin SA analogs, chromomycin SA 3 and chromomycin SA 2, along with deacetylchromomycin A 3 and five previously reported chromomycin analogs were isolated from a marine-derived Streptomyces sp. The structures of the new compounds were determined by spectroscopic methods including 1D and 2D NMR techniques, HRMS and chemical methods. Chromomycin SA 3 and chromomycin SA 2 are the first naturally occuring chromomycin analogs with truncated side-chains. Biological evaluation of chromomycin analogs for cytotoxicity against two non-small cell lung cancer (NSCLC) cell-lines, A549 and HCC44, demonstrated a decrease in cytotoxicity for the truncated sides chain chromomycin analogs.

Original languageEnglish (US)
Pages (from-to)5183-5189
Number of pages7
JournalBioorganic and Medicinal Chemistry
Volume19
Issue number17
DOIs
StatePublished - Sep 1 2011

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Chromomycins
Streptomyces
Cytotoxicity
Cells
Non-Small Cell Lung Carcinoma

Keywords

  • Anti-cancer agents
  • Aureolic acid
  • Chromomycin
  • Isolation
  • Marine actinomycetes
  • Natural products

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Chromomycin SA analogs from a marine-derived Streptomyces sp. / Hu, Youcai; Espindola, Ana Paula D M; Stewart, Nathan A.; Wei, Shuguang; Posner, Bruce A.; MacMillan, John B.

In: Bioorganic and Medicinal Chemistry, Vol. 19, No. 17, 01.09.2011, p. 5183-5189.

Research output: Contribution to journalArticle

Hu, Youcai ; Espindola, Ana Paula D M ; Stewart, Nathan A. ; Wei, Shuguang ; Posner, Bruce A. ; MacMillan, John B. / Chromomycin SA analogs from a marine-derived Streptomyces sp. In: Bioorganic and Medicinal Chemistry. 2011 ; Vol. 19, No. 17. pp. 5183-5189.
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