Abstract
Two chromomycin SA analogs, chromomycin SA 3 and chromomycin SA 2, along with deacetylchromomycin A 3 and five previously reported chromomycin analogs were isolated from a marine-derived Streptomyces sp. The structures of the new compounds were determined by spectroscopic methods including 1D and 2D NMR techniques, HRMS and chemical methods. Chromomycin SA 3 and chromomycin SA 2 are the first naturally occuring chromomycin analogs with truncated side-chains. Biological evaluation of chromomycin analogs for cytotoxicity against two non-small cell lung cancer (NSCLC) cell-lines, A549 and HCC44, demonstrated a decrease in cytotoxicity for the truncated sides chain chromomycin analogs.
Original language | English (US) |
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Pages (from-to) | 5183-5189 |
Number of pages | 7 |
Journal | Bioorganic and Medicinal Chemistry |
Volume | 19 |
Issue number | 17 |
DOIs | |
State | Published - Sep 1 2011 |
Keywords
- Anti-cancer agents
- Aureolic acid
- Chromomycin
- Isolation
- Marine actinomycetes
- Natural products
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry