Chromosomal loop anchorage sites appear to be evolutionarily conserved

Peter N. Cockerill, William T. Garrard

Research output: Contribution to journalArticle

98 Scopus citations

Abstract

We have previously identified a class of DNA sequence elements, termed matrix association regions (MARs), which specifically bind to nuclear matrices in vitro and are believed to be at the bases of chromosomal loops in vivo [1]. Here we demonstrate that nuclear matrices prepared from the yeast Saccharomyces cerevisiae will specifically bind an MAR sequence derived from the mouse kappa light chain immunoglobulin gene. This suggests that both MAR sequences and their binding sites have been strongly evolutionarily conserved.

Original languageEnglish (US)
Pages (from-to)5-7
Number of pages3
JournalFEBS Letters
Volume204
Issue number1
DOIs
StatePublished - Aug 11 1986

Keywords

  • (Yeast)
  • Chromatin loop
  • Enhancer
  • Immunoglobulin gene
  • Nuclear matrix
  • Nuclear scaffold
  • Topoisomerase II

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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