Chromosome abnormalities in AIDS-associated lymphadenopathy

M. L. Alonso, M. E. Richardson, C. E. Metroka, J. A. Mouradian, P. R. Koduru, D. A. Filippa, R. S. Chaganti

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Cytogenetic studies were performed on direct and 24-hour culture preparations of eight lymph node biopsies from seven patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC)-associated lymphadenopathy in whom histological evidence of lymphoma was not detected. Three of these seven had chromosomal abnormalities, including chromosome instability in one and clonal chromosomal abnormalities in two; one of the latter was a t(8;14)(q24;q32). The remaining five showed normal karyotypes. Epstein-Barr virus (EBV) titers were elevated in all three patients that exhibited chromosome abnormalities, two of whom later developed malignant lymphoma. A control group of five patients with reactive lymphadenopathy not associated with AIDS failed to reveal chromosomal aberrations, but elevated EBV titers were present in two. These data are consistent with current views on the role of EBV and chromosome change in the development of lymphoma in immunodeficient states and suggest that karyotypically abnormal AIDS-related lymphadenopathy represents a prelymphomatous proliferation.

Original languageEnglish (US)
Pages (from-to)855-858
Number of pages4
JournalBlood
Volume69
Issue number3
StatePublished - 1987

Fingerprint

Chromosomes
Viruses
Chromosome Aberrations
Acquired Immunodeficiency Syndrome
Human Herpesvirus 4
Lymphoma
Viral Load
Biopsy
Aberrations
Chromosomal Instability
Karyotype
Cytogenetics
Lymph Nodes
Control Groups
Lymphadenopathy

ASJC Scopus subject areas

  • Hematology

Cite this

Alonso, M. L., Richardson, M. E., Metroka, C. E., Mouradian, J. A., Koduru, P. R., Filippa, D. A., & Chaganti, R. S. (1987). Chromosome abnormalities in AIDS-associated lymphadenopathy. Blood, 69(3), 855-858.

Chromosome abnormalities in AIDS-associated lymphadenopathy. / Alonso, M. L.; Richardson, M. E.; Metroka, C. E.; Mouradian, J. A.; Koduru, P. R.; Filippa, D. A.; Chaganti, R. S.

In: Blood, Vol. 69, No. 3, 1987, p. 855-858.

Research output: Contribution to journalArticle

Alonso, ML, Richardson, ME, Metroka, CE, Mouradian, JA, Koduru, PR, Filippa, DA & Chaganti, RS 1987, 'Chromosome abnormalities in AIDS-associated lymphadenopathy', Blood, vol. 69, no. 3, pp. 855-858.
Alonso ML, Richardson ME, Metroka CE, Mouradian JA, Koduru PR, Filippa DA et al. Chromosome abnormalities in AIDS-associated lymphadenopathy. Blood. 1987;69(3):855-858.
Alonso, M. L. ; Richardson, M. E. ; Metroka, C. E. ; Mouradian, J. A. ; Koduru, P. R. ; Filippa, D. A. ; Chaganti, R. S. / Chromosome abnormalities in AIDS-associated lymphadenopathy. In: Blood. 1987 ; Vol. 69, No. 3. pp. 855-858.
@article{a2cc749acae14c71bcf36689327a81cc,
title = "Chromosome abnormalities in AIDS-associated lymphadenopathy",
abstract = "Cytogenetic studies were performed on direct and 24-hour culture preparations of eight lymph node biopsies from seven patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC)-associated lymphadenopathy in whom histological evidence of lymphoma was not detected. Three of these seven had chromosomal abnormalities, including chromosome instability in one and clonal chromosomal abnormalities in two; one of the latter was a t(8;14)(q24;q32). The remaining five showed normal karyotypes. Epstein-Barr virus (EBV) titers were elevated in all three patients that exhibited chromosome abnormalities, two of whom later developed malignant lymphoma. A control group of five patients with reactive lymphadenopathy not associated with AIDS failed to reveal chromosomal aberrations, but elevated EBV titers were present in two. These data are consistent with current views on the role of EBV and chromosome change in the development of lymphoma in immunodeficient states and suggest that karyotypically abnormal AIDS-related lymphadenopathy represents a prelymphomatous proliferation.",
author = "Alonso, {M. L.} and Richardson, {M. E.} and Metroka, {C. E.} and Mouradian, {J. A.} and Koduru, {P. R.} and Filippa, {D. A.} and Chaganti, {R. S.}",
year = "1987",
language = "English (US)",
volume = "69",
pages = "855--858",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "3",

}

TY - JOUR

T1 - Chromosome abnormalities in AIDS-associated lymphadenopathy

AU - Alonso, M. L.

AU - Richardson, M. E.

AU - Metroka, C. E.

AU - Mouradian, J. A.

AU - Koduru, P. R.

AU - Filippa, D. A.

AU - Chaganti, R. S.

PY - 1987

Y1 - 1987

N2 - Cytogenetic studies were performed on direct and 24-hour culture preparations of eight lymph node biopsies from seven patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC)-associated lymphadenopathy in whom histological evidence of lymphoma was not detected. Three of these seven had chromosomal abnormalities, including chromosome instability in one and clonal chromosomal abnormalities in two; one of the latter was a t(8;14)(q24;q32). The remaining five showed normal karyotypes. Epstein-Barr virus (EBV) titers were elevated in all three patients that exhibited chromosome abnormalities, two of whom later developed malignant lymphoma. A control group of five patients with reactive lymphadenopathy not associated with AIDS failed to reveal chromosomal aberrations, but elevated EBV titers were present in two. These data are consistent with current views on the role of EBV and chromosome change in the development of lymphoma in immunodeficient states and suggest that karyotypically abnormal AIDS-related lymphadenopathy represents a prelymphomatous proliferation.

AB - Cytogenetic studies were performed on direct and 24-hour culture preparations of eight lymph node biopsies from seven patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC)-associated lymphadenopathy in whom histological evidence of lymphoma was not detected. Three of these seven had chromosomal abnormalities, including chromosome instability in one and clonal chromosomal abnormalities in two; one of the latter was a t(8;14)(q24;q32). The remaining five showed normal karyotypes. Epstein-Barr virus (EBV) titers were elevated in all three patients that exhibited chromosome abnormalities, two of whom later developed malignant lymphoma. A control group of five patients with reactive lymphadenopathy not associated with AIDS failed to reveal chromosomal aberrations, but elevated EBV titers were present in two. These data are consistent with current views on the role of EBV and chromosome change in the development of lymphoma in immunodeficient states and suggest that karyotypically abnormal AIDS-related lymphadenopathy represents a prelymphomatous proliferation.

UR - http://www.scopus.com/inward/record.url?scp=0023113808&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023113808&partnerID=8YFLogxK

M3 - Article

C2 - 3028537

AN - SCOPUS:0023113808

VL - 69

SP - 855

EP - 858

JO - Blood

JF - Blood

SN - 0006-4971

IS - 3

ER -