Chronic 3,4-methylenedioxymethamphetamine treatment suppresses cell proliferation in the adult mouse dentate gyrus

Kyung Ok Cho, Seul Ki Kim, Gyu Seek Rhee, Seung Jun Kwack, Dae Hyun Cho, Ki Wug Sung, Seong Yun Kim

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We investigated the influence of chronic 3,4-methylenedioxymethamphetamine (MDMA) treatment on cell proliferation in the adult dentate gyrus. Mice were orally treated with MDMA (1.25 mg/kg-40 mg/kg) or saline for 30 days. To label dividing cells, mice were given 5-bromo-2′-deoxyuridine (BrdU) for 4 days from the day after the last administration of MDMA, and their brains were examined 24 h later. MDMA dose-dependently induced a decrease in the number of BrdU-positive cells in the male and female dentate gyrus. Our results suggest that chronic exposure to MDMA suppresses cell proliferation in the dentate gyrus.

Original languageEnglish (US)
Pages (from-to)120-123
Number of pages4
JournalEuropean Journal of Pharmacology
Volume566
Issue number1-3
DOIs
StatePublished - Jul 2 2007

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N-Methyl-3,4-methylenedioxyamphetamine
Dentate Gyrus
Cell Proliferation
Deoxyuridine
Bromodeoxyuridine
Brain

Keywords

  • Cell proliferation
  • Dentate gyrus
  • Ecstasy
  • Hippocampus
  • MDMA

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Chronic 3,4-methylenedioxymethamphetamine treatment suppresses cell proliferation in the adult mouse dentate gyrus. / Cho, Kyung Ok; Kim, Seul Ki; Rhee, Gyu Seek; Kwack, Seung Jun; Cho, Dae Hyun; Sung, Ki Wug; Kim, Seong Yun.

In: European Journal of Pharmacology, Vol. 566, No. 1-3, 02.07.2007, p. 120-123.

Research output: Contribution to journalArticle

Cho, Kyung Ok ; Kim, Seul Ki ; Rhee, Gyu Seek ; Kwack, Seung Jun ; Cho, Dae Hyun ; Sung, Ki Wug ; Kim, Seong Yun. / Chronic 3,4-methylenedioxymethamphetamine treatment suppresses cell proliferation in the adult mouse dentate gyrus. In: European Journal of Pharmacology. 2007 ; Vol. 566, No. 1-3. pp. 120-123.
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