Chronic 3,4-methylenedioxymethamphetamine treatment suppresses cell proliferation in the adult mouse dentate gyrus

Kyung Ok Cho; Seul Ki Kim; Gyu Seek Rhee; Seung Jun Kwack; Dae Hyun Cho; Ki Wug Sung; Seong Yun Kim

doi:10.1016/j.ejphar.2007.04.008

Chronic 3,4-methylenedioxymethamphetamine treatment suppresses cell proliferation in the adult mouse dentate gyrus

Kyung Ok Cho, Seul Ki Kim, Gyu Seek Rhee, Seung Jun Kwack, Dae Hyun Cho, Ki Wug Sung, Seong Yun Kim

Molecular Biology

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

We investigated the influence of chronic 3,4-methylenedioxymethamphetamine (MDMA) treatment on cell proliferation in the adult dentate gyrus. Mice were orally treated with MDMA (1.25 mg/kg-40 mg/kg) or saline for 30 days. To label dividing cells, mice were given 5-bromo-2′-deoxyuridine (BrdU) for 4 days from the day after the last administration of MDMA, and their brains were examined 24 h later. MDMA dose-dependently induced a decrease in the number of BrdU-positive cells in the male and female dentate gyrus. Our results suggest that chronic exposure to MDMA suppresses cell proliferation in the dentate gyrus.

Original language	English (US)
Pages (from-to)	120-123
Number of pages	4
Journal	European Journal of Pharmacology
Volume	566
Issue number	1-3
DOIs	https://doi.org/10.1016/j.ejphar.2007.04.008
State	Published - Jul 2 2007

Keywords

Cell proliferation
Dentate gyrus
Ecstasy
Hippocampus
MDMA

ASJC Scopus subject areas

Pharmacology

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10.1016/j.ejphar.2007.04.008

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@article{35868acffcd94de19ecfab5ad8e35393,

title = "Chronic 3,4-methylenedioxymethamphetamine treatment suppresses cell proliferation in the adult mouse dentate gyrus",

abstract = "We investigated the influence of chronic 3,4-methylenedioxymethamphetamine (MDMA) treatment on cell proliferation in the adult dentate gyrus. Mice were orally treated with MDMA (1.25 mg/kg-40 mg/kg) or saline for 30 days. To label dividing cells, mice were given 5-bromo-2′-deoxyuridine (BrdU) for 4 days from the day after the last administration of MDMA, and their brains were examined 24 h later. MDMA dose-dependently induced a decrease in the number of BrdU-positive cells in the male and female dentate gyrus. Our results suggest that chronic exposure to MDMA suppresses cell proliferation in the dentate gyrus.",

keywords = "Cell proliferation, Dentate gyrus, Ecstasy, Hippocampus, MDMA",

author = "Cho, {Kyung Ok} and Kim, {Seul Ki} and Rhee, {Gyu Seek} and Kwack, {Seung Jun} and Cho, {Dae Hyun} and Sung, {Ki Wug} and Kim, {Seong Yun}",

note = "Funding Information: This research was supported by a grant (06132485) from the Korea Food and Drug Administration in 2006.",

year = "2007",

month = jul,

day = "2",

doi = "10.1016/j.ejphar.2007.04.008",

language = "English (US)",

volume = "566",

pages = "120--123",

journal = "European Journal of Pharmacology",

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T1 - Chronic 3,4-methylenedioxymethamphetamine treatment suppresses cell proliferation in the adult mouse dentate gyrus

AU - Cho, Kyung Ok

AU - Kim, Seul Ki

AU - Rhee, Gyu Seek

AU - Kwack, Seung Jun

AU - Cho, Dae Hyun

AU - Sung, Ki Wug

AU - Kim, Seong Yun

N1 - Funding Information: This research was supported by a grant (06132485) from the Korea Food and Drug Administration in 2006.

PY - 2007/7/2

Y1 - 2007/7/2

N2 - We investigated the influence of chronic 3,4-methylenedioxymethamphetamine (MDMA) treatment on cell proliferation in the adult dentate gyrus. Mice were orally treated with MDMA (1.25 mg/kg-40 mg/kg) or saline for 30 days. To label dividing cells, mice were given 5-bromo-2′-deoxyuridine (BrdU) for 4 days from the day after the last administration of MDMA, and their brains were examined 24 h later. MDMA dose-dependently induced a decrease in the number of BrdU-positive cells in the male and female dentate gyrus. Our results suggest that chronic exposure to MDMA suppresses cell proliferation in the dentate gyrus.

AB - We investigated the influence of chronic 3,4-methylenedioxymethamphetamine (MDMA) treatment on cell proliferation in the adult dentate gyrus. Mice were orally treated with MDMA (1.25 mg/kg-40 mg/kg) or saline for 30 days. To label dividing cells, mice were given 5-bromo-2′-deoxyuridine (BrdU) for 4 days from the day after the last administration of MDMA, and their brains were examined 24 h later. MDMA dose-dependently induced a decrease in the number of BrdU-positive cells in the male and female dentate gyrus. Our results suggest that chronic exposure to MDMA suppresses cell proliferation in the dentate gyrus.

KW - Cell proliferation

KW - Dentate gyrus

KW - Ecstasy

KW - Hippocampus

KW - MDMA

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JF - European Journal of Pharmacology

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ER -

Chronic 3,4-methylenedioxymethamphetamine treatment suppresses cell proliferation in the adult mouse dentate gyrus

Abstract

Keywords

ASJC Scopus subject areas

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