Chronic 3,4-methylenedioxymethamphetamine treatment suppresses cell proliferation in the adult mouse dentate gyrus

Kyung Ok Cho, Seul Ki Kim, Gyu Seek Rhee, Seung Jun Kwack, Dae Hyun Cho, Ki Wug Sung, Seong Yun Kim

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

We investigated the influence of chronic 3,4-methylenedioxymethamphetamine (MDMA) treatment on cell proliferation in the adult dentate gyrus. Mice were orally treated with MDMA (1.25 mg/kg-40 mg/kg) or saline for 30 days. To label dividing cells, mice were given 5-bromo-2′-deoxyuridine (BrdU) for 4 days from the day after the last administration of MDMA, and their brains were examined 24 h later. MDMA dose-dependently induced a decrease in the number of BrdU-positive cells in the male and female dentate gyrus. Our results suggest that chronic exposure to MDMA suppresses cell proliferation in the dentate gyrus.

Original languageEnglish (US)
Pages (from-to)120-123
Number of pages4
JournalEuropean Journal of Pharmacology
Volume566
Issue number1-3
DOIs
StatePublished - Jul 2 2007

Keywords

  • Cell proliferation
  • Dentate gyrus
  • Ecstasy
  • Hippocampus
  • MDMA

ASJC Scopus subject areas

  • Pharmacology

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