Chronic membranous glomerulonephritis caused by hepatitis B antigen antibody immune complexes

P. F. Kohler, R. E. Cronin, W. S. Hammond, D. Olin, R. I. Carr

Research output: Contribution to journalArticle

92 Scopus citations

Abstract

The immunopathogenesis of chronic membranous glomerulonephritis was investigated in a 42 yr old man with chronic active hepatitis, type B. In 2 renal biopsies, 14 mth apart, immunofluorescent study showed glomerular deposition of the hepatitis B antigen (HB Ag) and host IgG, IgM, and C3 in an irregular ''immune complex'' pattern. Electron microscopy showed dense deposits in the thickened basement membrane but no morphologic evidence of the intact, spherical, 20 nm HB Ag. Low concentrations of HB Ag were found in serial serum samples whereas total complement and component concentrations were normal. Most significantly, circulating HB Ag antibody complexes were directly shown by serum cryoprecipitation. Results of in vitro tests for a cell mediated immune response to HB Ag were negative. The potential importance of chronic hepatitis B virus infection as a primary cause of human immune complex glomerulonephritis is supported by these findings.

Original languageEnglish (US)
Pages (from-to)448-451
Number of pages4
JournalUnknown Journal
Volume81
Issue number4
DOIs
StatePublished - Jan 1 1974

ASJC Scopus subject areas

  • Internal Medicine

Fingerprint Dive into the research topics of 'Chronic membranous glomerulonephritis caused by hepatitis B antigen antibody immune complexes'. Together they form a unique fingerprint.

  • Cite this