Chronic membranous glomerulonephritis caused by hepatitis B antigen antibody immune complexes

P. F. Kohler, R. E. Cronin, W. S. Hammond, D. Olin, R. I. Carr

Research output: Contribution to journalArticle

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Abstract

The immunopathogenesis of chronic membranous glomerulonephritis was investigated in a 42 yr old man with chronic active hepatitis, type B. In 2 renal biopsies, 14 mth apart, immunofluorescent study showed glomerular deposition of the hepatitis B antigen (HB Ag) and host IgG, IgM, and C3 in an irregular ''immune complex'' pattern. Electron microscopy showed dense deposits in the thickened basement membrane but no morphologic evidence of the intact, spherical, 20 nm HB Ag. Low concentrations of HB Ag were found in serial serum samples whereas total complement and component concentrations were normal. Most significantly, circulating HB Ag antibody complexes were directly shown by serum cryoprecipitation. Results of in vitro tests for a cell mediated immune response to HB Ag were negative. The potential importance of chronic hepatitis B virus infection as a primary cause of human immune complex glomerulonephritis is supported by these findings.

Original languageEnglish (US)
Pages (from-to)448-451
Number of pages4
JournalAnnals of Internal Medicine
Volume81
Issue number4
StatePublished - 1974

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Hepatitis B Antigens
Hepatitis B Antibodies
Membranous Glomerulonephritis
Antigen-Antibody Complex
Chronic Hepatitis B
Virus Diseases
Chronic Hepatitis
Glomerulonephritis
Serum
Basement Membrane
Hepatitis B virus
Immunoglobulin M
Electron Microscopy
Immunoglobulin G
Kidney
Biopsy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kohler, P. F., Cronin, R. E., Hammond, W. S., Olin, D., & Carr, R. I. (1974). Chronic membranous glomerulonephritis caused by hepatitis B antigen antibody immune complexes. Annals of Internal Medicine, 81(4), 448-451.

Chronic membranous glomerulonephritis caused by hepatitis B antigen antibody immune complexes. / Kohler, P. F.; Cronin, R. E.; Hammond, W. S.; Olin, D.; Carr, R. I.

In: Annals of Internal Medicine, Vol. 81, No. 4, 1974, p. 448-451.

Research output: Contribution to journalArticle

Kohler, PF, Cronin, RE, Hammond, WS, Olin, D & Carr, RI 1974, 'Chronic membranous glomerulonephritis caused by hepatitis B antigen antibody immune complexes', Annals of Internal Medicine, vol. 81, no. 4, pp. 448-451.
Kohler, P. F. ; Cronin, R. E. ; Hammond, W. S. ; Olin, D. ; Carr, R. I. / Chronic membranous glomerulonephritis caused by hepatitis B antigen antibody immune complexes. In: Annals of Internal Medicine. 1974 ; Vol. 81, No. 4. pp. 448-451.
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