Chronic sensory-motor activity in behaving animals using regenerative multi-electrode interfaces

V. H. Desai, S. Anand, M. Tran, A. Kanneganti, S. Vasudevan, J. L. Seifert, J. Cheng, E. W. Keefer, M. I. Romero-Ortega

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Citations (Scopus)

Abstract

Regenerative peripheral nerve interfaces have been proposed as viable alternatives for the natural control and feel of robotic prosthetic limbs. We have developed a Regenerative Multi-electrode Interface (REMI) that guides re-growing axons through an electrode array deployed in the lumen of a nerve guide. While acute studies have shown the use of the REMI in the rat sciatic nerve, the quality of chronic signal recording has not been reported. Here we show that implantation of this interface in the sciatic nerve is stable with high quality recordings up to 120 days and failures mainly attributable to abiotic factors related to pedestal detachment and wire breakage. We further tested the interfacing of REMI with fascicles of the sciatic nerve that primarily innervate muscles (tibial) and skin (sural). When implanted into the tibial nerve, bursting activity was observed synchronous to stepping. However, implantation of REMI into the sural nerve failed due to its small size. While fascicles smaller than 300 μm are a challenge for regenerative interfacing, we show that a modified REMI can be used in an insertion mode to record sensory signals from skin. In summary, the REMI represents an effective tool for recording firing patterns of specific axon types during voluntary movement, which may be used to improve the motor control and sensory feedback in closed loop control systems for robotic prosthesis.

Original languageEnglish (US)
Title of host publication2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1973-1976
Number of pages4
ISBN (Print)9781424479290
DOIs
StatePublished - Nov 2 2014
Event2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 - Chicago, United States
Duration: Aug 26 2014Aug 30 2014

Other

Other2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
CountryUnited States
CityChicago
Period8/26/148/30/14

Fingerprint

Electrodes
Animals
Motor Activity
Sciatic Nerve
Robotics
Axons
Skin
Sensory feedback
Closed loop control systems
Tibial Nerve
Sural Nerve
Sensory Feedback
Prosthetics
Peripheral Nerves
Prostheses and Implants
Muscle
Rats
Extremities
Wire
Muscles

ASJC Scopus subject areas

  • Health Informatics
  • Computer Science Applications
  • Biomedical Engineering

Cite this

Desai, V. H., Anand, S., Tran, M., Kanneganti, A., Vasudevan, S., Seifert, J. L., ... Romero-Ortega, M. I. (2014). Chronic sensory-motor activity in behaving animals using regenerative multi-electrode interfaces. In 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 (pp. 1973-1976). [6944000] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2014.6944000

Chronic sensory-motor activity in behaving animals using regenerative multi-electrode interfaces. / Desai, V. H.; Anand, S.; Tran, M.; Kanneganti, A.; Vasudevan, S.; Seifert, J. L.; Cheng, J.; Keefer, E. W.; Romero-Ortega, M. I.

2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014. Institute of Electrical and Electronics Engineers Inc., 2014. p. 1973-1976 6944000.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Desai, VH, Anand, S, Tran, M, Kanneganti, A, Vasudevan, S, Seifert, JL, Cheng, J, Keefer, EW & Romero-Ortega, MI 2014, Chronic sensory-motor activity in behaving animals using regenerative multi-electrode interfaces. in 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014., 6944000, Institute of Electrical and Electronics Engineers Inc., pp. 1973-1976, 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014, Chicago, United States, 8/26/14. https://doi.org/10.1109/EMBC.2014.6944000
Desai VH, Anand S, Tran M, Kanneganti A, Vasudevan S, Seifert JL et al. Chronic sensory-motor activity in behaving animals using regenerative multi-electrode interfaces. In 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014. Institute of Electrical and Electronics Engineers Inc. 2014. p. 1973-1976. 6944000 https://doi.org/10.1109/EMBC.2014.6944000
Desai, V. H. ; Anand, S. ; Tran, M. ; Kanneganti, A. ; Vasudevan, S. ; Seifert, J. L. ; Cheng, J. ; Keefer, E. W. ; Romero-Ortega, M. I. / Chronic sensory-motor activity in behaving animals using regenerative multi-electrode interfaces. 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014. Institute of Electrical and Electronics Engineers Inc., 2014. pp. 1973-1976
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