Circular reasoning: microRNAs and cell-cycle control

Raghu R. Chivukula, Joshua T. Mendell

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) have attracted considerable attention because of their important roles in development, normal physiology, and disease states including cancer. Recent studies have identified specific miRNAs that regulate the cell cycle and have documented that the loss or gain of miRNA-mediated cell-cycle control contributes to malignancy. miRNAs regulate classic cell-cycle control pathways by directly targeting proteins such as E2F transcription factors, cyclin-dependent kinases (Cdks), cyclins and Cdk inhibitors. Moreover, from recent findings, it has been suggested that miRNAs themselves might be subject to cell-cycle dependent regulation. Together, these observations indicate that the reciprocal control of RNA silencing and the metazoan cell cycle impacts cellular behavior and disease.

Original languageEnglish (US)
Pages (from-to)474-481
Number of pages8
JournalTrends in Biochemical Sciences
Volume33
Issue number10
DOIs
StatePublished - Oct 2008

Fingerprint

Cell Cycle Checkpoints
MicroRNAs
Cells
Cell Cycle
E2F Transcription Factors
Cyclins
Cyclin-Dependent Kinases
Physiology
Protein Transport
RNA Interference
Neoplasms
RNA
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Circular reasoning : microRNAs and cell-cycle control. / Chivukula, Raghu R.; Mendell, Joshua T.

In: Trends in Biochemical Sciences, Vol. 33, No. 10, 10.2008, p. 474-481.

Research output: Contribution to journalArticle

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