Circulating angiogenic factors in singleton vs multiple-gestation pregnancies

Sharon E. Maynard, Tiffany A. Moore Simas, Matthew J. Solitro, Abraham Rajan, Sybil Crawford, Peter Soderland, Bruce A. Meyer

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Objective: Placental soluble fms-like tyrosine kinase-1 may contribute to the pathogenesis of preeclampsia. Here we describe alterations in serum angiogenic factor levels in women with multiple gestation pregnancies, a major preeclampsia risk factor. Study Design: We collected serial serum specimens from 101 pregnant women at high preeclampsia risk between 22 and 36 weeks' gestation. Soluble fms-like tyrosine kinase-1 and placental growth factor were measured by enzyme-linked immunosorbent assay. Women who had preeclampsia or gestational hypertension develop were excluded. Results: Maternal soluble fms-like tyrosine kinase-1 was higher in multiple gestation (n = 20) compared with high-risk singleton (n = 81) pregnancies for each gestational age range examined. Maternal placental growth factor was significantly higher in multiple vs high-risk singletons before 31 weeks' gestation, whereas the soluble fms-like tyrosine kinase-1/placental growth factor ratio was higher in multiple vs high-risk singletons after 27 weeks. Conclusion: Alterations in circulating angiogenic factors are present in women with multiple gestations and may contribute to higher preeclampsia risk in this population.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume198
Issue number2
DOIs
StatePublished - Feb 2008

Fingerprint

Multiple Pregnancy
Angiogenesis Inducing Agents
Vascular Endothelial Growth Factor Receptor-1
Pre-Eclampsia
Pregnancy
Intercellular Signaling Peptides and Proteins
Mothers
Pregnancy Induced Hypertension
Serum
Gestational Age
Pregnant Women
Enzyme-Linked Immunosorbent Assay
Population

Keywords

  • angiogenic proteins
  • multiple pregnancy
  • preeclampsia
  • twins

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Circulating angiogenic factors in singleton vs multiple-gestation pregnancies. / Maynard, Sharon E.; Moore Simas, Tiffany A.; Solitro, Matthew J.; Rajan, Abraham; Crawford, Sybil; Soderland, Peter; Meyer, Bruce A.

In: American Journal of Obstetrics and Gynecology, Vol. 198, No. 2, 02.2008.

Research output: Contribution to journalArticle

Maynard, Sharon E. ; Moore Simas, Tiffany A. ; Solitro, Matthew J. ; Rajan, Abraham ; Crawford, Sybil ; Soderland, Peter ; Meyer, Bruce A. / Circulating angiogenic factors in singleton vs multiple-gestation pregnancies. In: American Journal of Obstetrics and Gynecology. 2008 ; Vol. 198, No. 2.
@article{11f3c4685cfc4b81965dc4afe90dee2a,
title = "Circulating angiogenic factors in singleton vs multiple-gestation pregnancies",
abstract = "Objective: Placental soluble fms-like tyrosine kinase-1 may contribute to the pathogenesis of preeclampsia. Here we describe alterations in serum angiogenic factor levels in women with multiple gestation pregnancies, a major preeclampsia risk factor. Study Design: We collected serial serum specimens from 101 pregnant women at high preeclampsia risk between 22 and 36 weeks' gestation. Soluble fms-like tyrosine kinase-1 and placental growth factor were measured by enzyme-linked immunosorbent assay. Women who had preeclampsia or gestational hypertension develop were excluded. Results: Maternal soluble fms-like tyrosine kinase-1 was higher in multiple gestation (n = 20) compared with high-risk singleton (n = 81) pregnancies for each gestational age range examined. Maternal placental growth factor was significantly higher in multiple vs high-risk singletons before 31 weeks' gestation, whereas the soluble fms-like tyrosine kinase-1/placental growth factor ratio was higher in multiple vs high-risk singletons after 27 weeks. Conclusion: Alterations in circulating angiogenic factors are present in women with multiple gestations and may contribute to higher preeclampsia risk in this population.",
keywords = "angiogenic proteins, multiple pregnancy, preeclampsia, twins",
author = "Maynard, {Sharon E.} and {Moore Simas}, {Tiffany A.} and Solitro, {Matthew J.} and Abraham Rajan and Sybil Crawford and Peter Soderland and Meyer, {Bruce A.}",
year = "2008",
month = "2",
doi = "10.1016/j.ajog.2007.08.042",
language = "English (US)",
volume = "198",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "2",

}

TY - JOUR

T1 - Circulating angiogenic factors in singleton vs multiple-gestation pregnancies

AU - Maynard, Sharon E.

AU - Moore Simas, Tiffany A.

AU - Solitro, Matthew J.

AU - Rajan, Abraham

AU - Crawford, Sybil

AU - Soderland, Peter

AU - Meyer, Bruce A.

PY - 2008/2

Y1 - 2008/2

N2 - Objective: Placental soluble fms-like tyrosine kinase-1 may contribute to the pathogenesis of preeclampsia. Here we describe alterations in serum angiogenic factor levels in women with multiple gestation pregnancies, a major preeclampsia risk factor. Study Design: We collected serial serum specimens from 101 pregnant women at high preeclampsia risk between 22 and 36 weeks' gestation. Soluble fms-like tyrosine kinase-1 and placental growth factor were measured by enzyme-linked immunosorbent assay. Women who had preeclampsia or gestational hypertension develop were excluded. Results: Maternal soluble fms-like tyrosine kinase-1 was higher in multiple gestation (n = 20) compared with high-risk singleton (n = 81) pregnancies for each gestational age range examined. Maternal placental growth factor was significantly higher in multiple vs high-risk singletons before 31 weeks' gestation, whereas the soluble fms-like tyrosine kinase-1/placental growth factor ratio was higher in multiple vs high-risk singletons after 27 weeks. Conclusion: Alterations in circulating angiogenic factors are present in women with multiple gestations and may contribute to higher preeclampsia risk in this population.

AB - Objective: Placental soluble fms-like tyrosine kinase-1 may contribute to the pathogenesis of preeclampsia. Here we describe alterations in serum angiogenic factor levels in women with multiple gestation pregnancies, a major preeclampsia risk factor. Study Design: We collected serial serum specimens from 101 pregnant women at high preeclampsia risk between 22 and 36 weeks' gestation. Soluble fms-like tyrosine kinase-1 and placental growth factor were measured by enzyme-linked immunosorbent assay. Women who had preeclampsia or gestational hypertension develop were excluded. Results: Maternal soluble fms-like tyrosine kinase-1 was higher in multiple gestation (n = 20) compared with high-risk singleton (n = 81) pregnancies for each gestational age range examined. Maternal placental growth factor was significantly higher in multiple vs high-risk singletons before 31 weeks' gestation, whereas the soluble fms-like tyrosine kinase-1/placental growth factor ratio was higher in multiple vs high-risk singletons after 27 weeks. Conclusion: Alterations in circulating angiogenic factors are present in women with multiple gestations and may contribute to higher preeclampsia risk in this population.

KW - angiogenic proteins

KW - multiple pregnancy

KW - preeclampsia

KW - twins

UR - http://www.scopus.com/inward/record.url?scp=38349172463&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38349172463&partnerID=8YFLogxK

U2 - 10.1016/j.ajog.2007.08.042

DO - 10.1016/j.ajog.2007.08.042

M3 - Article

C2 - 18226624

AN - SCOPUS:38349172463

VL - 198

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 2

ER -