TY - JOUR
T1 - Circulating immune complexes
T2 - Their immunochemistry, biology, and detection in selected dermatologic and systemic diseases
AU - Yancey, K. B.
AU - Lawley, T. J.
N1 - Funding Information:
:.AAD~ The CME articles are made possible through an "~'.~'~,/ educational grant from Syntex Laboratories, Inc. From the Dermatology Branch, National Cancer Institute, National Institutes of Health. Reprint requests to; Dr. Kim B. Yaneey, Dermatology Branch, Bldg. 10, Room 12N238, National Institutes of Health, Bethesda, MD 20205.
PY - 1984
Y1 - 1984
N2 - Circulating immune complexes (CICs) are a heterogeneous group of immunoreactants formed by the noncovalent union of antigen and antibody. Many factors influence the formation, immunochemistry, biology, and clearance of these soluble reactants. The recent development of sensitive assays for the detection of CICs and the capability to assess immune complex (IC) clearance mechanisms in humans in vivo have expanded our understanding of these mediators. CICs influence both the afferent and efferent limbs of the immune response and can mediate tissue damage in certain pathologic states. ICs probably play an important role in the pathogenesis of serum sickness, systemic lupus erythematosus, and cutaneous necrotizing vasculitis. Recent investigations have raised the possibility that CICs may be of significance in other types of vasculitis as well. In other instances, ICs may form in response to tissue injury and subsequently modify the immune response of the host. A review of this material with special emphasis on diseases of relevance to dermatologists is presented.
AB - Circulating immune complexes (CICs) are a heterogeneous group of immunoreactants formed by the noncovalent union of antigen and antibody. Many factors influence the formation, immunochemistry, biology, and clearance of these soluble reactants. The recent development of sensitive assays for the detection of CICs and the capability to assess immune complex (IC) clearance mechanisms in humans in vivo have expanded our understanding of these mediators. CICs influence both the afferent and efferent limbs of the immune response and can mediate tissue damage in certain pathologic states. ICs probably play an important role in the pathogenesis of serum sickness, systemic lupus erythematosus, and cutaneous necrotizing vasculitis. Recent investigations have raised the possibility that CICs may be of significance in other types of vasculitis as well. In other instances, ICs may form in response to tissue injury and subsequently modify the immune response of the host. A review of this material with special emphasis on diseases of relevance to dermatologists is presented.
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U2 - 10.1016/S0190-9622(84)70087-9
DO - 10.1016/S0190-9622(84)70087-9
M3 - Article
C2 - 6233339
AN - SCOPUS:0021349630
SN - 0190-9622
VL - 10
SP - 711
EP - 731
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 5
ER -