Citric-acid-derived photo-cross-linked biodegradable elastomers

Dipendra Gyawali, Richard T. Tran, Kristine J. Guleserian, Liping Tang, Jian Yang

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Citric-acid-derived thermally cross-linked biodegradable elastomers (CABEs) have recently received significant attention in various biomedical applications, including tissue-engineering orthopedic devices, bioimaging and implant coatings. However, citric-acid-derived photo-cross-linked biodegradable elastomers are rarely reported. Herein, we report a novel photo-cross-linked biodegradable elastomer, referred to as poly(octamethylene maleate citrate) (POMC), which preserves pendant hydroxyl and carboxylic functionalities after cross-linking for the potential conjugation of biologically active molecules. Pre-POMC is a low-molecular-mass pre-polymer with an average molecular mass between 701 and 1291 Da. POMC networks are soft and elastic with an initial modulus of 0.07 to 1.3 MPa and an elongation-at-break between 38 and 382%. FT-IR-ATR results confirmed the successful surface immobilization of type-I collagen onto POMC films, which enhanced in vitro cellular attachment and proliferation. Photo-polymerized POMC films implanted subcutaneously into Sprague-Dawley rats demonstrated minimal in vivo inflammatory responses. The development of POMC enriches the family of citric-acid-derived biodegradable elastomers and expands the available biodegradable polymers for versatile needs in biomedical applications.

Original languageEnglish (US)
Pages (from-to)1761-1782
Number of pages22
JournalJournal of Biomaterials Science, Polymer Edition
Volume21
Issue number13
DOIs
StatePublished - Sep 1 2010

Keywords

  • Elastomer
  • biodegradable
  • citric acid
  • photo-cross-linking
  • tissue engineering
  • wound dressing

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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