Citric-acid-derived photo-cross-linked biodegradable elastomers

Dipendra Gyawali, Richard T. Tran, Kristine J. Guleserian, Liping Tang, Jian Yang

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Citric-acid-derived thermally cross-linked biodegradable elastomers (CABEs) have recently received significant attention in various biomedical applications, including tissue-engineering orthopedic devices, bioimaging and implant coatings. However, citric-acid-derived photo-cross-linked biodegradable elastomers are rarely reported. Herein, we report a novel photo-cross-linked biodegradable elastomer, referred to as poly(octamethylene maleate citrate) (POMC), which preserves pendant hydroxyl and carboxylic functionalities after cross-linking for the potential conjugation of biologically active molecules. Pre-POMC is a low-molecular-mass pre-polymer with an average molecular mass between 701 and 1291 Da. POMC networks are soft and elastic with an initial modulus of 0.07 to 1.3 MPa and an elongation-at-break between 38 and 382%. FT-IR-ATR results confirmed the successful surface immobilization of type-I collagen onto POMC films, which enhanced in vitro cellular attachment and proliferation. Photo-polymerized POMC films implanted subcutaneously into Sprague-Dawley rats demonstrated minimal in vivo inflammatory responses. The development of POMC enriches the family of citric-acid-derived biodegradable elastomers and expands the available biodegradable polymers for versatile needs in biomedical applications.

Original languageEnglish (US)
Pages (from-to)1761-1782
Number of pages22
JournalJournal of Biomaterials Science, Polymer Edition
Volume21
Issue number13
DOIs
StatePublished - Sep 1 2010

Fingerprint

Elastomers
Citric acid
Citric Acid
Molecular mass
Biodegradable polymers
Polymers
Orthopedics
Tissue engineering
Collagen
Rats
Elongation
Tissue Engineering
Collagen Type I
Immobilization
Hydroxyl Radical
Coatings
Molecules
Sprague Dawley Rats
poly(octamethylene maleate citrate)
Cell Proliferation

Keywords

  • biodegradable
  • citric acid
  • Elastomer
  • photo-cross-linking
  • tissue engineering
  • wound dressing

ASJC Scopus subject areas

  • Biophysics
  • Biomaterials
  • Bioengineering
  • Biomedical Engineering

Cite this

Citric-acid-derived photo-cross-linked biodegradable elastomers. / Gyawali, Dipendra; Tran, Richard T.; Guleserian, Kristine J.; Tang, Liping; Yang, Jian.

In: Journal of Biomaterials Science, Polymer Edition, Vol. 21, No. 13, 01.09.2010, p. 1761-1782.

Research output: Contribution to journalArticle

Gyawali, Dipendra ; Tran, Richard T. ; Guleserian, Kristine J. ; Tang, Liping ; Yang, Jian. / Citric-acid-derived photo-cross-linked biodegradable elastomers. In: Journal of Biomaterials Science, Polymer Edition. 2010 ; Vol. 21, No. 13. pp. 1761-1782.
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