Clinical and molecular diagnosis of pathologic complete response in rectal cancer

Prachi M. Patel, Kelly Harris, Sergio Huerta

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The current standard approach to locally advanced rectal cancer involves pre-operative chemoradiotherapy followed by total mesorectal excision. This practice is supported by several studies that have demonstrated superior local control with this approach. This strategy, leads to a pathologic complete response (pCR) in a substantial proportion of patients treated with neoadjuvant therapy. Furthermore, pCR has been shown to be a reliable predictor of improved oncologic outcomes. This observation has led to an increased interest in the pursuit of identifying clinical, radiographic, pathologic and biochemical predictors of pCR. This review discusses the promising approaches to and most recent advancements in predicting pCR in rectal cancer.

Original languageEnglish (US)
Pages (from-to)1505-1516
Number of pages12
JournalExpert Review of Molecular Diagnostics
Volume15
Issue number11
DOIs
StatePublished - Nov 2 2015

Keywords

  • abdominoperineal resection
  • chemoradiation
  • clinical complete response
  • ionizing radiation
  • low anterior resection
  • lymphocyte to monocyte ratio
  • radiation therapy
  • tumor regression grade

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pathology and Forensic Medicine

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