Clinical features of depressed outpatients with and without co-occurring general medical conditions in STAR*D

William R. Yates, Jeff Mitchell, A. John Rush, Madhukar H. Trivedi, Stephen R. Wisniewski, Diane Warden, Robert B. Hauger, Maurizio Fava, Bradley N. Gaynes, Mustafa M. Husain, Charlene Bryan

Research output: Contribution to journalArticlepeer-review

100 Scopus citations


A significant percentage of patients with major depressive disorder (MDD) suffer from concurrent general medical conditions (GMCs). The objective of this preliminary report was to describe the rates of co-occurring significant GMCs and the clinical correlates and symptom features associated with the presence of GMCs. Baseline cross-sectional case-control study of patients enrolling in a prospective randomized multistage treatment study of MDD. Fourteen regional U.S. centers representing 19 primary care and 22 psychiatric practices. One thousand five hundred outpatients with DSM-IV nonpsychotic MDD. Sociodemographic status, medical illness ratings, psychiatric status, quality of life and DSM-IV depression symptom ratings. The prevalence of significant medical comorbidity in this population was 52.8% (95% CI 50.3-55.3%). Concurrent significant medical comorbidity was associated with older age, lower income, unemployment, limited education, longer duration of index depressive episode and absence of self-reported family history of depression. Somatic symptoms common in MDD were endorsed at a higher rate in those with GMCs. Those without a GMC had higher rates of endorsement of impaired mood reactivity, distinct mood quality and interpersonal sensitivity. Concurrent GMCs are common among outpatients with MDD in both primary care and specialty settings. Concurrent GMCs appear to influence the severity and symptom patterns in MDD and describe a vulnerable population with sociodemographic challenges to effective assessment and treatment.

Original languageEnglish (US)
Pages (from-to)421-429
Number of pages9
JournalGeneral Hospital Psychiatry
Issue number6
StatePublished - Nov 2004


  • Depression
  • General medical conditions
  • Major depressive disorder
  • STAR*D

ASJC Scopus subject areas

  • Psychiatry and Mental health


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