Clinical importance of the cytochromes P450

Daniel W. Nebert, David W. Russell

Research output: Contribution to journalReview article

962 Scopus citations

Abstract

The human cytochrome P450 (CYP) superfamily comprises 57 genes. These genes code for enzymes that can have a role in: metabolism of drugs, foreign chemicals, arachidonic acid and eicosanoids; cholesterol metabolism and bile-acid biosynthesis; steroid synthesis and metabolism; vitamin D3 synthesis and metabolism; retinoic acid hydroxylation; and those of still unknown function. Cytochrome P450 was once believed to be mainly a hepatic drug detoxication system, but is now understood to include a myriad of enzymic reactions implicated in important life processes. Mutations in many CYP genes cause inborn errors of metabolism and contribute to many clinically relevant diseases.

Original languageEnglish (US)
Pages (from-to)1155-1162
Number of pages8
JournalLancet
Volume360
Issue number9340
DOIs
StatePublished - Oct 12 2002

ASJC Scopus subject areas

  • Medicine(all)

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