Clinical Outcomes and Cost Comparisons of Stent and Non-Stent Interventions in Infrainguinal Peripheral Artery Disease: Insights From the Excellence in Peripheral Artery Disease (XLPAD) Registry

Subhash Banerjee, Haekyung Jeon-Slaughter, Ehrin J. Armstrong, Christopher Bajzer, Mazen Abu-Fadel, Houman Khalili, Anand Prasad, Bassel Bou Dargham, Preeti Kamath, Tayo Addo, Michael Luna, Osvaldo Gigliotti, Mazin Foteh, Ian Cawich, Scott Kinlay, Mujtaba Ali, Bala Ramanan, Khusrow Niazi, Shirling Tsai, Nicolas W. ShammasEmmanouil S Brilakis

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

BACKGROUND: The contemporary limb outcomes and costs of stent-based vs non-stent based strategies in endovascular revascularization of femoropopliteal (FP) peripheral artery disease (PAD) are not well understood. METHODS AND RESULTS: We present data from the ongoing United States multicenter Excellence in Peripheral Artery Disease Registry between 2006-2016 to compare stent vs non-stent treatment outcomes and associated costs in FP interventions. A total of 2910 FP interventions were performed in 2162 patients (mean age, 66 years), comprising 1339 stent based (superficial femoral artery, 93%) in 1007 patients and 1571 non-stent interventions (superficial femoral artery, 85%) in 1155 patients. A growing trend for non-stent based interventions and a declining trend in repeat revascularization rate at 1 year were observed across years of registry enrollment. Stent implantation was the prevailing strategy in treating longer FP lesions (mean length, 152 mm vs 105 mm; P<.001) and chronic total occlusions (65% vs 40%; P<.001), while stent implantation was employed less frequently when treating in-stent restenotic lesions (14% vs 20%; P<.001). Stent and non-stent interventions had similar 1-year limb outcomes in all-cause death, target-limb revascularization, target-vessel revascularization, and major or minor amputation. The average procedure costs for the stent group were significantly higher than the non-stent group ($6215 vs $4790; P<.001). CONCLUSION: There is a growing trend for non-stent FP artery interventions, with a significant decline in 1-year target-limb revascularization rates over time. One-year limb outcomes in stent-based compared to non-stent interventions are similar; however, at a significantly higher procedural cost.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalThe Journal of invasive cardiology
Volume31
Issue number1
StatePublished - Jan 1 2019

Keywords

  • chronic total occlusions
  • superficial femoral artery

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Clinical Outcomes and Cost Comparisons of Stent and Non-Stent Interventions in Infrainguinal Peripheral Artery Disease: Insights From the Excellence in Peripheral Artery Disease (XLPAD) Registry'. Together they form a unique fingerprint.

  • Cite this

    Banerjee, S., Jeon-Slaughter, H., Armstrong, E. J., Bajzer, C., Abu-Fadel, M., Khalili, H., Prasad, A., Bou Dargham, B., Kamath, P., Addo, T., Luna, M., Gigliotti, O., Foteh, M., Cawich, I., Kinlay, S., Ali, M., Ramanan, B., Niazi, K., Tsai, S., ... Brilakis, E. S. (2019). Clinical Outcomes and Cost Comparisons of Stent and Non-Stent Interventions in Infrainguinal Peripheral Artery Disease: Insights From the Excellence in Peripheral Artery Disease (XLPAD) Registry. The Journal of invasive cardiology, 31(1), 1-9.