Clinical pharmacology of methicillin in neonates

Larrie D. Sarff, George H. McCracken, Marion L. Thomas, Linda J. Horton, Norma Threlkeld

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The pharmacokinetic properties of methicillin were investigated in 59 newborn infants. Concentrations of methicillin in serum were approximately 58 and 80 μg/ml at one hour after 25 and 50 mg/kg doses, respectively. The average serum half-life values ranged from one to three hours and were inversely correlated with birth weight and chronologic age. The half-life values, volumes of distribution, and plasma clearances of methicillin are shown in relationship to gestational age and chronologic age. A dosage of 25 mg/kg is recommended for therapy of most neonatal staphylococcal diseases; the frequency of administration is altered on the basis of birth weight and chronologic age.

Original languageEnglish (US)
Pages (from-to)1005-1008
Number of pages4
JournalThe Journal of Pediatrics
Volume90
Issue number6
DOIs
StatePublished - 1977

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Methicillin
Clinical Pharmacology
Newborn Infant
Birth Weight
Half-Life
Infant, Newborn, Diseases
Plasma Volume
Serum
Gestational Age
Pharmacokinetics
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Clinical pharmacology of methicillin in neonates. / Sarff, Larrie D.; McCracken, George H.; Thomas, Marion L.; Horton, Linda J.; Threlkeld, Norma.

In: The Journal of Pediatrics, Vol. 90, No. 6, 1977, p. 1005-1008.

Research output: Contribution to journalArticle

Sarff, LD, McCracken, GH, Thomas, ML, Horton, LJ & Threlkeld, N 1977, 'Clinical pharmacology of methicillin in neonates', The Journal of Pediatrics, vol. 90, no. 6, pp. 1005-1008. https://doi.org/10.1016/S0022-3476(77)80582-9
Sarff, Larrie D. ; McCracken, George H. ; Thomas, Marion L. ; Horton, Linda J. ; Threlkeld, Norma. / Clinical pharmacology of methicillin in neonates. In: The Journal of Pediatrics. 1977 ; Vol. 90, No. 6. pp. 1005-1008.
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