Clinician, parent, and child prediction of medication or placebo in double-blind depression study

Carroll W. Hughes, Graham Emslie, Robert Kowatch, Warren Weinberg, Jeanne Rintelmann, A. John Rush

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

To evaluate how well a blind is maintained in a double-blind study. Clinicians (n = 66), parents (n = 62), and depressed child/adolescent subjects (n = 62) predicted whether the patient had been on either placebo or active medication at the end of an eight-week double-blind placebo versus fluoxetine trial. Clinician, patient and parents' guesses as to which treatment they had received were at a chance level based on an overall analysis. However, when clinical response and condition assignment were controlled, all were correctly predicting placebo treatment but not medication treatment. The finding that subjects, parents and clinicians predict at a chance level is important for double-blind study design integrity. However, clinicians, parents and subjects were accurately predicting placebo treatment when clinical response and the assigned condition were taken into account but not medication. Since they do not know condition however, all remain essentially blinded, and this is an important finding for design and analysis integrity for double-blind studies. (C) 2000 American College of Neuropsychopharmacology.

Original languageEnglish (US)
Pages (from-to)591-594
Number of pages4
JournalNeuropsychopharmacology
Volume23
Issue number5
DOIs
StatePublished - Nov 2000

Fingerprint

Double-Blind Method
Parents
Placebos
Depression
Fluoxetine
Therapeutics

Keywords

  • Childhood depression
  • Double-blind
  • Fluoxetine
  • MDD
  • Placebo
  • Prediction

ASJC Scopus subject areas

  • Pharmacology

Cite this

Clinician, parent, and child prediction of medication or placebo in double-blind depression study. / Hughes, Carroll W.; Emslie, Graham; Kowatch, Robert; Weinberg, Warren; Rintelmann, Jeanne; Rush, A. John.

In: Neuropsychopharmacology, Vol. 23, No. 5, 11.2000, p. 591-594.

Research output: Contribution to journalArticle

Hughes, Carroll W. ; Emslie, Graham ; Kowatch, Robert ; Weinberg, Warren ; Rintelmann, Jeanne ; Rush, A. John. / Clinician, parent, and child prediction of medication or placebo in double-blind depression study. In: Neuropsychopharmacology. 2000 ; Vol. 23, No. 5. pp. 591-594.
@article{679866a3d8654f2bb6ced44eb209af4f,
title = "Clinician, parent, and child prediction of medication or placebo in double-blind depression study",
abstract = "To evaluate how well a blind is maintained in a double-blind study. Clinicians (n = 66), parents (n = 62), and depressed child/adolescent subjects (n = 62) predicted whether the patient had been on either placebo or active medication at the end of an eight-week double-blind placebo versus fluoxetine trial. Clinician, patient and parents' guesses as to which treatment they had received were at a chance level based on an overall analysis. However, when clinical response and condition assignment were controlled, all were correctly predicting placebo treatment but not medication treatment. The finding that subjects, parents and clinicians predict at a chance level is important for double-blind study design integrity. However, clinicians, parents and subjects were accurately predicting placebo treatment when clinical response and the assigned condition were taken into account but not medication. Since they do not know condition however, all remain essentially blinded, and this is an important finding for design and analysis integrity for double-blind studies. (C) 2000 American College of Neuropsychopharmacology.",
keywords = "Childhood depression, Double-blind, Fluoxetine, MDD, Placebo, Prediction",
author = "Hughes, {Carroll W.} and Graham Emslie and Robert Kowatch and Warren Weinberg and Jeanne Rintelmann and Rush, {A. John}",
year = "2000",
month = "11",
doi = "10.1016/S0893-133X(00)00098-1",
language = "English (US)",
volume = "23",
pages = "591--594",
journal = "Neuropsychopharmacology",
issn = "0893-133X",
publisher = "Nature Publishing Group",
number = "5",

}

TY - JOUR

T1 - Clinician, parent, and child prediction of medication or placebo in double-blind depression study

AU - Hughes, Carroll W.

AU - Emslie, Graham

AU - Kowatch, Robert

AU - Weinberg, Warren

AU - Rintelmann, Jeanne

AU - Rush, A. John

PY - 2000/11

Y1 - 2000/11

N2 - To evaluate how well a blind is maintained in a double-blind study. Clinicians (n = 66), parents (n = 62), and depressed child/adolescent subjects (n = 62) predicted whether the patient had been on either placebo or active medication at the end of an eight-week double-blind placebo versus fluoxetine trial. Clinician, patient and parents' guesses as to which treatment they had received were at a chance level based on an overall analysis. However, when clinical response and condition assignment were controlled, all were correctly predicting placebo treatment but not medication treatment. The finding that subjects, parents and clinicians predict at a chance level is important for double-blind study design integrity. However, clinicians, parents and subjects were accurately predicting placebo treatment when clinical response and the assigned condition were taken into account but not medication. Since they do not know condition however, all remain essentially blinded, and this is an important finding for design and analysis integrity for double-blind studies. (C) 2000 American College of Neuropsychopharmacology.

AB - To evaluate how well a blind is maintained in a double-blind study. Clinicians (n = 66), parents (n = 62), and depressed child/adolescent subjects (n = 62) predicted whether the patient had been on either placebo or active medication at the end of an eight-week double-blind placebo versus fluoxetine trial. Clinician, patient and parents' guesses as to which treatment they had received were at a chance level based on an overall analysis. However, when clinical response and condition assignment were controlled, all were correctly predicting placebo treatment but not medication treatment. The finding that subjects, parents and clinicians predict at a chance level is important for double-blind study design integrity. However, clinicians, parents and subjects were accurately predicting placebo treatment when clinical response and the assigned condition were taken into account but not medication. Since they do not know condition however, all remain essentially blinded, and this is an important finding for design and analysis integrity for double-blind studies. (C) 2000 American College of Neuropsychopharmacology.

KW - Childhood depression

KW - Double-blind

KW - Fluoxetine

KW - MDD

KW - Placebo

KW - Prediction

UR - http://www.scopus.com/inward/record.url?scp=0033802272&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033802272&partnerID=8YFLogxK

U2 - 10.1016/S0893-133X(00)00098-1

DO - 10.1016/S0893-133X(00)00098-1

M3 - Article

C2 - 11027925

AN - SCOPUS:0033802272

VL - 23

SP - 591

EP - 594

JO - Neuropsychopharmacology

JF - Neuropsychopharmacology

SN - 0893-133X

IS - 5

ER -