Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: Identity of human and porcine endothelin

Yasuaki Itoh, Masashi Yanagisawa, Shoichi Ohkubo, Chiharu Kimura, Takuo Kosaka, Akihiro Inoue, Norio Ishida, Youji Mitsui, Haruo Onda, Masahiko Fujino, Tomoh Masaki

Research output: Contribution to journalArticle

377 Scopus citations


A cDNA encoding a human endothelium-derived vasoconstrictor peptide, endothelin, was isolated from a human placenta cDNA library. The nucleotide sequence of this cDNA clone showed that the primary structure of the human preproendothelin has 212 amino acid residues and is highly homologous to porcine preproendothelin, and that human endothelin is identical with porcine endothelin.

Original languageEnglish (US)
Pages (from-to)440-444
Number of pages5
JournalFEBS Letters
Issue number2
StatePublished - Apr 25 1988



  • (Endothelium)
  • Cardiovascular physiology
  • Endothelin
  • Peptide processing
  • Vasoconstrictor peptide
  • cDNA cloning

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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