Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: Identity of human and porcine endothelin

Yasuaki Itoh; Masashi Yanagisawa; Shoichi Ohkubo; Chiharu Kimura; Takuo Kosaka; Akihiro Inoue; Norio Ishida; Youji Mitsui; Haruo Onda; Masahiko Fujino; Tomoh Masaki

doi:10.1016/0014-5793(88)80867-6

Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: Identity of human and porcine endothelin

Yasuaki Itoh, Masashi Yanagisawa, Shoichi Ohkubo, Chiharu Kimura, Takuo Kosaka, Akihiro Inoue, Norio Ishida, Youji Mitsui, Haruo Onda, Masahiko Fujino, Tomoh Masaki

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Abstract

A cDNA encoding a human endothelium-derived vasoconstrictor peptide, endothelin, was isolated from a human placenta cDNA library. The nucleotide sequence of this cDNA clone showed that the primary structure of the human preproendothelin has 212 amino acid residues and is highly homologous to porcine preproendothelin, and that human endothelin is identical with porcine endothelin.

Original language	English (US)
Pages (from-to)	440-444
Number of pages	5
Journal	FEBS Letters
Volume	231
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(88)80867-6
State	Published - Apr 25 1988

Keywords

(Endothelium)
Cardiovascular physiology
Endothelin
Peptide processing
Vasoconstrictor peptide
cDNA cloning

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/0014-5793(88)80867-6

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Itoh, Y., Yanagisawa, M., Ohkubo, S., Kimura, C., Kosaka, T., Inoue, A., Ishida, N., Mitsui, Y., Onda, H., Fujino, M., & Masaki, T. (1988). Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: Identity of human and porcine endothelin. FEBS Letters, 231(2), 440-444. https://doi.org/10.1016/0014-5793(88)80867-6

Itoh, Y, Yanagisawa, M, Ohkubo, S, Kimura, C, Kosaka, T, Inoue, A, Ishida, N, Mitsui, Y, Onda, H, Fujino, M & Masaki, T 1988, 'Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: Identity of human and porcine endothelin', FEBS Letters, vol. 231, no. 2, pp. 440-444. https://doi.org/10.1016/0014-5793(88)80867-6

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T1 - Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin

T2 - Identity of human and porcine endothelin

AU - Itoh, Yasuaki

AU - Yanagisawa, Masashi

AU - Ohkubo, Shoichi

AU - Kimura, Chiharu

AU - Kosaka, Takuo

AU - Inoue, Akihiro

AU - Ishida, Norio

AU - Mitsui, Youji

AU - Onda, Haruo

AU - Fujino, Masahiko

AU - Masaki, Tomoh

PY - 1988/4/25

Y1 - 1988/4/25

N2 - A cDNA encoding a human endothelium-derived vasoconstrictor peptide, endothelin, was isolated from a human placenta cDNA library. The nucleotide sequence of this cDNA clone showed that the primary structure of the human preproendothelin has 212 amino acid residues and is highly homologous to porcine preproendothelin, and that human endothelin is identical with porcine endothelin.

AB - A cDNA encoding a human endothelium-derived vasoconstrictor peptide, endothelin, was isolated from a human placenta cDNA library. The nucleotide sequence of this cDNA clone showed that the primary structure of the human preproendothelin has 212 amino acid residues and is highly homologous to porcine preproendothelin, and that human endothelin is identical with porcine endothelin.

KW - (Endothelium)

KW - Cardiovascular physiology

KW - Endothelin

KW - Peptide processing

KW - Vasoconstrictor peptide

KW - cDNA cloning

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Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: Identity of human and porcine endothelin

Abstract

Keywords

ASJC Scopus subject areas

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