Coated pits,coated vesicles,and receptor-mediated endocytosis

Joseph L. Goldstein, Richard G W Anderson, Michael S. Brown

Research output: Contribution to journalArticle

1248 Scopus citations

Abstract

Proteins and peptides can enter cells by receptor-mediated endocytosis, a coupled process by which selected extracellular proteins or peptides are first bound to specific cell surface receptors and then rapidly internalised by the cell Internalisation follows clustering of the receptors in specialised regions of the cell surface called coated pits that invaginate to form intracellular coated vesicles. It is now recognised that receptor-mediated endocytosis has a fundamental role in the growth, nutrition and differentiation of animal cells.

Original languageEnglish (US)
Pages (from-to)679-685
Number of pages7
JournalNature
Volume279
Issue number5715
DOIs
Publication statusPublished - 1979

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