Cochlear vessel permeability to horseradish peroxidase after diuretic administration in the Chinchilla

Arndt J. Duvall, Karen S. Robinson

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The permeability of strial vessels to the small protein, HRP, was examined after administration of diuretics to determine if increased vascular permeability is a factor in the development of strial edema as it is in acoustic trauma. Chinchillas were injected with HRP and either ethacrynic acid, a loop-inhibiting diuretic, or mannitol, an osmotic diuretic. There was no increased vascular permeability to HRP. Therefore, unlike the increased vessel permeability of HRP seen after an acoustic insult, increased vessel permeability of HRP is not a factor in the formation of strial edema after either mannitol or ethacrynic acid administration.

Original languageEnglish (US)
Pages (from-to)397-403
Number of pages7
JournalActa Oto-Laryngologica
Volume108
Issue number5-6
DOIs
StatePublished - 1989

Fingerprint

Chinchilla
Cochlea
Horseradish Peroxidase
Diuretics
Ethacrynic Acid
Permeability
Capillary Permeability
Mannitol
Edema
Osmotic Diuretics
Sodium Potassium Chloride Symporter Inhibitors
Noise-Induced Hearing Loss
Acoustics
Proteins

Keywords

  • Ethacrynic acid
  • Mannitol
  • Stria vascularis

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Cochlear vessel permeability to horseradish peroxidase after diuretic administration in the Chinchilla. / Duvall, Arndt J.; Robinson, Karen S.

In: Acta Oto-Laryngologica, Vol. 108, No. 5-6, 1989, p. 397-403.

Research output: Contribution to journalArticle

Duvall, Arndt J. ; Robinson, Karen S. / Cochlear vessel permeability to horseradish peroxidase after diuretic administration in the Chinchilla. In: Acta Oto-Laryngologica. 1989 ; Vol. 108, No. 5-6. pp. 397-403.
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