Coencapsulation of arsenic-and platinum-based drugs for targeted cancer treatment

Haimei Chen; Samuel Pazicni; Nancy L. Krett; Richard W. Ahn; James E. Penner-Hahn; Steven T. Rosen; Thomas V. O'Halloran

doi:10.1002/anie.200903655

Coencapsulation of arsenic-and platinum-based drugs for targeted cancer treatment

Haimei Chen, Samuel Pazicni, Nancy L. Krett, Richard W. Ahn, James E. Penner-Hahn, Steven T. Rosen, Thomas V. O'Halloran

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

(Figure Presented) Two In one: A novel strategy for efficiently coencapsulating both arsenic- and platinum-based drugs into 100 nm-scale liposomes (NBs) relies on the formation of Pt^IIAs^III adducts. This co-loaded system presents a robust platform for further modification with targeting ligands and affords a method of improving the therapeutic efficacy of anticancer agents.

Original language	English (US)
Pages (from-to)	9295-9299
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	49
DOIs	https://doi.org/10.1002/anie.200903655
State	Published - Nov 23 2009
Externally published	Yes

Keywords

Arsenic trioxide
Cisplatin
Coencapsulation
Liposome
Targeted delivery

ASJC Scopus subject areas

Catalysis
General Chemistry

Access to Document

10.1002/anie.200903655

Cite this

@article{e04da31da24443d592d9288d7c5a220c,

title = "Coencapsulation of arsenic-and platinum-based drugs for targeted cancer treatment",

abstract = "(Figure Presented) Two In one: A novel strategy for efficiently coencapsulating both arsenic- and platinum-based drugs into 100 nm-scale liposomes (NBs) relies on the formation of PtIIAsIII adducts. This co-loaded system presents a robust platform for further modification with targeting ligands and affords a method of improving the therapeutic efficacy of anticancer agents.",

keywords = "Arsenic trioxide, Cisplatin, Coencapsulation, Liposome, Targeted delivery",

author = "Haimei Chen and Samuel Pazicni and Krett, {Nancy L.} and Ahn, {Richard W.} and Penner-Hahn, {James E.} and Rosen, {Steven T.} and O'Halloran, {Thomas V.}",

year = "2009",

month = nov,

day = "23",

doi = "10.1002/anie.200903655",

language = "English (US)",

volume = "48",

pages = "9295--9299",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "49",

}

TY - JOUR

T1 - Coencapsulation of arsenic-and platinum-based drugs for targeted cancer treatment

AU - Chen, Haimei

AU - Pazicni, Samuel

AU - Krett, Nancy L.

AU - Ahn, Richard W.

AU - Penner-Hahn, James E.

AU - Rosen, Steven T.

AU - O'Halloran, Thomas V.

PY - 2009/11/23

Y1 - 2009/11/23

N2 - (Figure Presented) Two In one: A novel strategy for efficiently coencapsulating both arsenic- and platinum-based drugs into 100 nm-scale liposomes (NBs) relies on the formation of PtIIAsIII adducts. This co-loaded system presents a robust platform for further modification with targeting ligands and affords a method of improving the therapeutic efficacy of anticancer agents.

AB - (Figure Presented) Two In one: A novel strategy for efficiently coencapsulating both arsenic- and platinum-based drugs into 100 nm-scale liposomes (NBs) relies on the formation of PtIIAsIII adducts. This co-loaded system presents a robust platform for further modification with targeting ligands and affords a method of improving the therapeutic efficacy of anticancer agents.

KW - Arsenic trioxide

KW - Cisplatin

KW - Coencapsulation

KW - Liposome

KW - Targeted delivery

UR - http://www.scopus.com/inward/record.url?scp=72949088654&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=72949088654&partnerID=8YFLogxK

U2 - 10.1002/anie.200903655

DO - 10.1002/anie.200903655

M3 - Article

C2 - 19894238

AN - SCOPUS:72949088654

SN - 1433-7851

VL - 48

SP - 9295

EP - 9299

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 49

ER -

Coencapsulation of arsenic-and platinum-based drugs for targeted cancer treatment

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this