TY - JOUR
T1 - Cognitive decline in short and long sleepers
T2 - A prospective population-based study (NEDICES)
AU - Benito-León, Julián
AU - Louis, Elan D.
AU - Bermejo-Pareja, Félix
N1 - Funding Information:
The Spanish Health Research Agency and the Spanish Office of Science and Technology supported NEDICES. Dr. Benito-León is supported by the National Institutes of Health, Bethesda, MD, USA (R01 NS039422), the Commission of the European Union (grant ICT-2011-287739, NeuroTREMOR), and the Spanish Health Research Agency (grant FIS PI12/01602). Dr. Bermejo-Pareja is supported by NIH R01 NS039422 from the National Institutes of Health, Bethesda, MD, USA and from the Commission of the European Union (grant ICT-2011-287739, NeuroTREMOR). Dr. Elan D. Louis has received research support from the National Institutes of Health, Bethesda, MD, USA: NINDS #R01 NS042859 (principal investigator), NINDS #R01 NS39422 (principal investigator), NINDS #T32 NS07153-24 (principal investigator), NINDS #R01 NS073872 (principal investigator), NINDS #R21 NS077094 (co-Investigator), and NINDS #R01 NS36630 (co-Investigator), as well as the Parkinson's disease Foundation (principal investigator).
PY - 2013/12
Y1 - 2013/12
N2 - Background: It is not clear whether cognitive decline progresses more quickly in long sleepers than in short sleepers or than in participants with usual sleep duration. We assessed cognitive decline as a function of self-reported sleep duration in a prospective population-based cohort (NEDICES). Methods: Participants were evaluated at baseline and 3 years later. Baseline demographic variables were recorded and participants indicated their daily sleep usual duration as the sum of nighttime sleep and daytime napping. The average daily total usual sleep duration was grouped into three categories: ≤5h (short sleepers), 6-8h (reference category), and ≥9h (long sleepers). At baseline and at follow-up, a 37-item version of the Mini-Mental State Examination (37-MMSE) was administered. Results: The final sample, 2715 participants (72.9±6.1 years), comprised 298 (11%) short sleepers, 1086 (40%) long sleepers, and 1331 (49%) in the reference group (6-8h). During the three year follow-up period, the 37-MMSE declined by 0.5±4.0 points in short sleepers, 0.6±4.3 points in long sleepers, and 0.2±3.8 points in the reference group ( p=0.08). The difference between short sleepers and the reference group was not significant ( p=0.142); however, the difference between long sleepers and the reference group was significant ( p=0.040). In analyses adjusted for baseline age and other potential confounders, this difference remained robust. Conclusions: In this study, cognitive test scores among long sleepers declined more rapidly than observed in a reference group. Additional studies are needed to confirm these results.
AB - Background: It is not clear whether cognitive decline progresses more quickly in long sleepers than in short sleepers or than in participants with usual sleep duration. We assessed cognitive decline as a function of self-reported sleep duration in a prospective population-based cohort (NEDICES). Methods: Participants were evaluated at baseline and 3 years later. Baseline demographic variables were recorded and participants indicated their daily sleep usual duration as the sum of nighttime sleep and daytime napping. The average daily total usual sleep duration was grouped into three categories: ≤5h (short sleepers), 6-8h (reference category), and ≥9h (long sleepers). At baseline and at follow-up, a 37-item version of the Mini-Mental State Examination (37-MMSE) was administered. Results: The final sample, 2715 participants (72.9±6.1 years), comprised 298 (11%) short sleepers, 1086 (40%) long sleepers, and 1331 (49%) in the reference group (6-8h). During the three year follow-up period, the 37-MMSE declined by 0.5±4.0 points in short sleepers, 0.6±4.3 points in long sleepers, and 0.2±3.8 points in the reference group ( p=0.08). The difference between short sleepers and the reference group was not significant ( p=0.142); however, the difference between long sleepers and the reference group was significant ( p=0.040). In analyses adjusted for baseline age and other potential confounders, this difference remained robust. Conclusions: In this study, cognitive test scores among long sleepers declined more rapidly than observed in a reference group. Additional studies are needed to confirm these results.
KW - Cognitive function
KW - Elderly
KW - Epidemiology
KW - Population-based study
KW - Sleep duration
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U2 - 10.1016/j.jpsychires.2013.09.007
DO - 10.1016/j.jpsychires.2013.09.007
M3 - Article
C2 - 24094933
AN - SCOPUS:84886086388
SN - 0022-3956
VL - 47
SP - 1998
EP - 2003
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
IS - 12
ER -