Cognitive Functioning in Late-life Depression: A Critical Review of Sociodemographic, Neurobiological, and Treatment Correlates

Vonetta M. Dotson, Sarah M. Szymkowicz, Joseph U. Kim, Shawn M. McClintock

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Purpose of Review: Both clinical and subthreshold depression in older adults are associated with cognitive dysfunction. This review summarizes the latest literature on patterns of cognitive functioning in late-life depression (LLD), including moderators of the relationship between depression and cognitive functioning and underlying neurobiological mechanisms. Recent Findings: LLD is associated with cognitive dysfunction across multiple domains, particularly processing speed and executive functions. This relationship is moderated by demographic and clinical variables such as sex, race, age of onset, and severity of different symptom dimensions of depression. The impact of depression treatment on cognitive deficits in LLD differs across treatment approaches, but overall LLD is associated with persistent cognitive deficits after depression remission. Summary: Clarifying treatments with dual mood and cognitive benefits is an important area for future research. Our understanding of and treatment for cognitive deficits in LLD will also benefit from additional work that examines clinical and demographic contributions.

Original languageEnglish (US)
Pages (from-to)310-318
Number of pages9
JournalCurrent Behavioral Neuroscience Reports
Volume5
Issue number4
DOIs
StatePublished - Dec 1 2018

Keywords

  • Cognitive decline
  • Cognitive impairment
  • Geriatric depression
  • Mood disorders
  • Older adults
  • Symptom dimensions

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Behavioral Neuroscience

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