Twenty-three patients with bone and soft tissue tumors were studied with combined magnetic resonance (MR) imaging and spectroscopy. The MR examinations were utilized to determine the size, internal characteristics, and relationships of the tumor to the surrounding tissues. They also determined the optimal placement of the surface coil. The surface coil profile was the localization technique utilized. Four patients were also studied with onedimensional chemical shift localization. Tumors were grouped according to histologic type, degree of muscle contamination, size, and extent of necrosis. Quantitative comparison among the groups was carried out by comparing the mean ratios of the low-energy phosphate portion of the spectra [phosphomono- ester (PME), Pi(phosphodiester (PDE)] to β-nucleotide triphosphate (NTP). Tumor spectra typically showed a relative elevation in PME, Pi and PDE and a relative decrease in phosphocreatinine. No characteristic spectra were observed for individual tymor types. Contamination of the tumor spectra from surrounding muscle impaired interpretation of the spectral data. Tumor size and extent of necrosis were important determinants of the relative degree of abnormally elevated metabolite peaks (PME, Pi PDE). A trend toward a higher mean PME/β-NTP ratio was observed among high-grade lesions. Combined MR imaging and spectroscopy is a useful way to study tumor metabolism. Muscle contamination is a significant problem in analysis of the spectra. Better localization techniques are required.
- Bones, neoplasms
- Magnetic resonance imaging
- Muscles, neoplasms
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging