COMMD1 regulates inflammation and colitis-associated cancer progression

Haiying Li, Ezra Burstein

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

NF-κB is a master transcriptional regulator of inflammation that plays an important role in oncogenesis, particularly in tumors that arise in the context of inflammation. Copper metabolism MURR1 domain-containing 1 (COMMD1) is a negative regulator of NF-κB. Recent genetic-based studies in both mice and human patients indicate that COMMD1 has an important role in controlling intestinal inflammation and constraining progression to colitis-associated cancer.

Original languageEnglish (US)
Article numbere947891
JournalOncoImmunology
Volume3
Issue number7
DOIs
StatePublished - Jan 1 2014

Keywords

  • COMMD1
  • Colitis-associated cancer
  • Inflammation
  • Inflammatory bowel disease
  • NF-κB
  • Ubiquitination

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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