Comparative effects of curcumin and photo-irradiated curcumin on alcohol- and polyunsaturated fatty acid-induced hyperlipidemia

R. Rukkumani, M. Sri Balasubashini, P. Vishwanathan, V. P. Menon

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

It is a known fact that ethanol increases lipid levels in humans and experimental animals. Reports show that the increased intake of polyunsaturated fatty acids (PUFAs) along with alcohol produces various pathological changes in liver resulting in hyperlipidemia. Heating of oil rich in PUFA produces various lipid peroxidative end products, which aggravate the pathological changes. In the present study, we have investigated the effect of curcumin (C) and photo-irradiated curcumin (IC) on alcohol- and PUFA-induced hyperlipidemia. Our results showed that the activities of alkaline phosphatase (ALP), γ-glutamyl transferase (GGT) in plasma and levels of cholesterol, triglycerides (TGs) and free fatty acids (FFAs) in tissues were increased significantly in both alcohol + raw as well as heated PUFA groups compared to normal, but decreased significantly on treatment with curcumin and IC. The IC treatment decreased the levels more significantly compared to curcumin. The phospholipids (PLs) were increased significantly in heart and intestine and decreased in liver and kidney in both alcohol + raw as well as heated PUFA groups. The levels were significantly decreased in liver and kidney and increased in intestine and heart in both curcumin- and IC-treated groups. But the effect of IC was more pronounced than curcumin. Histopathological observations were also in correlation with the biochemical parameters. Thus, photo-irradiated curcumin proves itself to be more effective than curcumin in treating the above pathological conditions.

Original languageEnglish (US)
Pages (from-to)257-264
Number of pages8
JournalPharmacological Research
Volume46
Issue number3
DOIs
StatePublished - Jan 1 2002

Fingerprint

Curcumin
Hyperlipidemias
Unsaturated Fatty Acids
Alcohols
Intestines
Liver
Kidney
Lipids
Transferases
Nonesterified Fatty Acids
Heating
Alkaline Phosphatase
Phospholipids
Oils
Triglycerides
Ethanol
Cholesterol

Keywords

  • Alcohol
  • Curcumin
  • Lipids
  • Photo-irradiated curcumin
  • PUFA

ASJC Scopus subject areas

  • Pharmacology

Cite this

Comparative effects of curcumin and photo-irradiated curcumin on alcohol- and polyunsaturated fatty acid-induced hyperlipidemia. / Rukkumani, R.; Sri Balasubashini, M.; Vishwanathan, P.; Menon, V. P.

In: Pharmacological Research, Vol. 46, No. 3, 01.01.2002, p. 257-264.

Research output: Contribution to journalArticle

Rukkumani, R. ; Sri Balasubashini, M. ; Vishwanathan, P. ; Menon, V. P. / Comparative effects of curcumin and photo-irradiated curcumin on alcohol- and polyunsaturated fatty acid-induced hyperlipidemia. In: Pharmacological Research. 2002 ; Vol. 46, No. 3. pp. 257-264.
@article{0a01d5f5b30a4cf4ad43d4205893283a,
title = "Comparative effects of curcumin and photo-irradiated curcumin on alcohol- and polyunsaturated fatty acid-induced hyperlipidemia",
abstract = "It is a known fact that ethanol increases lipid levels in humans and experimental animals. Reports show that the increased intake of polyunsaturated fatty acids (PUFAs) along with alcohol produces various pathological changes in liver resulting in hyperlipidemia. Heating of oil rich in PUFA produces various lipid peroxidative end products, which aggravate the pathological changes. In the present study, we have investigated the effect of curcumin (C) and photo-irradiated curcumin (IC) on alcohol- and PUFA-induced hyperlipidemia. Our results showed that the activities of alkaline phosphatase (ALP), γ-glutamyl transferase (GGT) in plasma and levels of cholesterol, triglycerides (TGs) and free fatty acids (FFAs) in tissues were increased significantly in both alcohol + raw as well as heated PUFA groups compared to normal, but decreased significantly on treatment with curcumin and IC. The IC treatment decreased the levels more significantly compared to curcumin. The phospholipids (PLs) were increased significantly in heart and intestine and decreased in liver and kidney in both alcohol + raw as well as heated PUFA groups. The levels were significantly decreased in liver and kidney and increased in intestine and heart in both curcumin- and IC-treated groups. But the effect of IC was more pronounced than curcumin. Histopathological observations were also in correlation with the biochemical parameters. Thus, photo-irradiated curcumin proves itself to be more effective than curcumin in treating the above pathological conditions.",
keywords = "Alcohol, Curcumin, Lipids, Photo-irradiated curcumin, PUFA",
author = "R. Rukkumani and {Sri Balasubashini}, M. and P. Vishwanathan and Menon, {V. P.}",
year = "2002",
month = "1",
day = "1",
doi = "10.1016/S1043-6618(02)00149-4",
language = "English (US)",
volume = "46",
pages = "257--264",
journal = "Pharmacological Research",
issn = "1043-6618",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Comparative effects of curcumin and photo-irradiated curcumin on alcohol- and polyunsaturated fatty acid-induced hyperlipidemia

AU - Rukkumani, R.

AU - Sri Balasubashini, M.

AU - Vishwanathan, P.

AU - Menon, V. P.

PY - 2002/1/1

Y1 - 2002/1/1

N2 - It is a known fact that ethanol increases lipid levels in humans and experimental animals. Reports show that the increased intake of polyunsaturated fatty acids (PUFAs) along with alcohol produces various pathological changes in liver resulting in hyperlipidemia. Heating of oil rich in PUFA produces various lipid peroxidative end products, which aggravate the pathological changes. In the present study, we have investigated the effect of curcumin (C) and photo-irradiated curcumin (IC) on alcohol- and PUFA-induced hyperlipidemia. Our results showed that the activities of alkaline phosphatase (ALP), γ-glutamyl transferase (GGT) in plasma and levels of cholesterol, triglycerides (TGs) and free fatty acids (FFAs) in tissues were increased significantly in both alcohol + raw as well as heated PUFA groups compared to normal, but decreased significantly on treatment with curcumin and IC. The IC treatment decreased the levels more significantly compared to curcumin. The phospholipids (PLs) were increased significantly in heart and intestine and decreased in liver and kidney in both alcohol + raw as well as heated PUFA groups. The levels were significantly decreased in liver and kidney and increased in intestine and heart in both curcumin- and IC-treated groups. But the effect of IC was more pronounced than curcumin. Histopathological observations were also in correlation with the biochemical parameters. Thus, photo-irradiated curcumin proves itself to be more effective than curcumin in treating the above pathological conditions.

AB - It is a known fact that ethanol increases lipid levels in humans and experimental animals. Reports show that the increased intake of polyunsaturated fatty acids (PUFAs) along with alcohol produces various pathological changes in liver resulting in hyperlipidemia. Heating of oil rich in PUFA produces various lipid peroxidative end products, which aggravate the pathological changes. In the present study, we have investigated the effect of curcumin (C) and photo-irradiated curcumin (IC) on alcohol- and PUFA-induced hyperlipidemia. Our results showed that the activities of alkaline phosphatase (ALP), γ-glutamyl transferase (GGT) in plasma and levels of cholesterol, triglycerides (TGs) and free fatty acids (FFAs) in tissues were increased significantly in both alcohol + raw as well as heated PUFA groups compared to normal, but decreased significantly on treatment with curcumin and IC. The IC treatment decreased the levels more significantly compared to curcumin. The phospholipids (PLs) were increased significantly in heart and intestine and decreased in liver and kidney in both alcohol + raw as well as heated PUFA groups. The levels were significantly decreased in liver and kidney and increased in intestine and heart in both curcumin- and IC-treated groups. But the effect of IC was more pronounced than curcumin. Histopathological observations were also in correlation with the biochemical parameters. Thus, photo-irradiated curcumin proves itself to be more effective than curcumin in treating the above pathological conditions.

KW - Alcohol

KW - Curcumin

KW - Lipids

KW - Photo-irradiated curcumin

KW - PUFA

UR - http://www.scopus.com/inward/record.url?scp=0036425263&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036425263&partnerID=8YFLogxK

U2 - 10.1016/S1043-6618(02)00149-4

DO - 10.1016/S1043-6618(02)00149-4

M3 - Article

C2 - 12220969

AN - SCOPUS:0036425263

VL - 46

SP - 257

EP - 264

JO - Pharmacological Research

JF - Pharmacological Research

SN - 1043-6618

IS - 3

ER -