Comparing the volume of gliomas in the brain in FLAIR and post-contrast T1-weighted MRI sequences.

Sheena Gurwara, Ahmad Azzawe, Shaunesse Jacobs, Ajay Ravi, Mardjohan Hardjasudarma, Eduardo Gonzalez Toledo

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The imaging modality used to diagnose and monitor brain gliomas is magnetic resonance imaging (MRI), with standard protocols including contrast-enhanced T1-weighted and fluid-attenuated inversion recovery (FLAIR) image sequences. Many clinical trials are currently using contrast-enhanced T1-weighted MR image sequences to evaluate tumor response to treatment, but it is our hypothesis that FLAIR sequences will detect higher tumor volumes and, therefore, should be the preferred image sequence for this purpose. In this retrospective study, a volumetric analysis was conducted on the post-contrast T1-weighted and FLAIR MR image sequences of 38 patients with confirmed brain gliomas. The two volumes were subsequently found to have a statistically significant positive correlation. The FLAIR volume was also found to be greater than the post-contrast T1-weighted volume in all 38 patients. As a result, FLAIR image sequences provide a more complete characterization of gliomas and may be more beneficial when observing tumor response after treatment.

Original languageEnglish (US)
Pages (from-to)265-266
Number of pages2
JournalThe Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society
Volume162
Issue number5
StatePublished - Jan 1 2010
Externally publishedYes

Fingerprint

Glioma
Magnetic Resonance Imaging
Brain
Sequence Inversion
Tumor Burden
Neoplasms
Retrospective Studies
Clinical Trials
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Comparing the volume of gliomas in the brain in FLAIR and post-contrast T1-weighted MRI sequences. / Gurwara, Sheena; Azzawe, Ahmad; Jacobs, Shaunesse; Ravi, Ajay; Hardjasudarma, Mardjohan; Toledo, Eduardo Gonzalez.

In: The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society, Vol. 162, No. 5, 01.01.2010, p. 265-266.

Research output: Contribution to journalArticle

Gurwara, Sheena ; Azzawe, Ahmad ; Jacobs, Shaunesse ; Ravi, Ajay ; Hardjasudarma, Mardjohan ; Toledo, Eduardo Gonzalez. / Comparing the volume of gliomas in the brain in FLAIR and post-contrast T1-weighted MRI sequences. In: The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society. 2010 ; Vol. 162, No. 5. pp. 265-266.
@article{236cf023308b49aca9060087ff9b9e4b,
title = "Comparing the volume of gliomas in the brain in FLAIR and post-contrast T1-weighted MRI sequences.",
abstract = "The imaging modality used to diagnose and monitor brain gliomas is magnetic resonance imaging (MRI), with standard protocols including contrast-enhanced T1-weighted and fluid-attenuated inversion recovery (FLAIR) image sequences. Many clinical trials are currently using contrast-enhanced T1-weighted MR image sequences to evaluate tumor response to treatment, but it is our hypothesis that FLAIR sequences will detect higher tumor volumes and, therefore, should be the preferred image sequence for this purpose. In this retrospective study, a volumetric analysis was conducted on the post-contrast T1-weighted and FLAIR MR image sequences of 38 patients with confirmed brain gliomas. The two volumes were subsequently found to have a statistically significant positive correlation. The FLAIR volume was also found to be greater than the post-contrast T1-weighted volume in all 38 patients. As a result, FLAIR image sequences provide a more complete characterization of gliomas and may be more beneficial when observing tumor response after treatment.",
author = "Sheena Gurwara and Ahmad Azzawe and Shaunesse Jacobs and Ajay Ravi and Mardjohan Hardjasudarma and Toledo, {Eduardo Gonzalez}",
year = "2010",
month = "1",
day = "1",
language = "English (US)",
volume = "162",
pages = "265--266",
journal = "The New Orleans medical and surgical journal",
issn = "0024-6921",
publisher = "Louisiana State Medical society",
number = "5",

}

TY - JOUR

T1 - Comparing the volume of gliomas in the brain in FLAIR and post-contrast T1-weighted MRI sequences.

AU - Gurwara, Sheena

AU - Azzawe, Ahmad

AU - Jacobs, Shaunesse

AU - Ravi, Ajay

AU - Hardjasudarma, Mardjohan

AU - Toledo, Eduardo Gonzalez

PY - 2010/1/1

Y1 - 2010/1/1

N2 - The imaging modality used to diagnose and monitor brain gliomas is magnetic resonance imaging (MRI), with standard protocols including contrast-enhanced T1-weighted and fluid-attenuated inversion recovery (FLAIR) image sequences. Many clinical trials are currently using contrast-enhanced T1-weighted MR image sequences to evaluate tumor response to treatment, but it is our hypothesis that FLAIR sequences will detect higher tumor volumes and, therefore, should be the preferred image sequence for this purpose. In this retrospective study, a volumetric analysis was conducted on the post-contrast T1-weighted and FLAIR MR image sequences of 38 patients with confirmed brain gliomas. The two volumes were subsequently found to have a statistically significant positive correlation. The FLAIR volume was also found to be greater than the post-contrast T1-weighted volume in all 38 patients. As a result, FLAIR image sequences provide a more complete characterization of gliomas and may be more beneficial when observing tumor response after treatment.

AB - The imaging modality used to diagnose and monitor brain gliomas is magnetic resonance imaging (MRI), with standard protocols including contrast-enhanced T1-weighted and fluid-attenuated inversion recovery (FLAIR) image sequences. Many clinical trials are currently using contrast-enhanced T1-weighted MR image sequences to evaluate tumor response to treatment, but it is our hypothesis that FLAIR sequences will detect higher tumor volumes and, therefore, should be the preferred image sequence for this purpose. In this retrospective study, a volumetric analysis was conducted on the post-contrast T1-weighted and FLAIR MR image sequences of 38 patients with confirmed brain gliomas. The two volumes were subsequently found to have a statistically significant positive correlation. The FLAIR volume was also found to be greater than the post-contrast T1-weighted volume in all 38 patients. As a result, FLAIR image sequences provide a more complete characterization of gliomas and may be more beneficial when observing tumor response after treatment.

UR - http://www.scopus.com/inward/record.url?scp=79952109347&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952109347&partnerID=8YFLogxK

M3 - Article

C2 - 21141258

AN - SCOPUS:79952109347

VL - 162

SP - 265

EP - 266

JO - The New Orleans medical and surgical journal

JF - The New Orleans medical and surgical journal

SN - 0024-6921

IS - 5

ER -