Comparison of CSF cytology and spinal magnetic resonance imaging in the detection of leptomeningeal disease in pediatric medulloblastoma or primitive neuroectodermal tumor

Maryam Fouladi, Amar Gajjar, James M. Boyett, Andrew W. Walter, Stephen J. Thompson, Thomas E. Merchant, Jesse J. Jenkins, James W. Langston, Aiyi Liu, Larry E. Kun, Richard L. Heideman

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Purpose: Leptomeningeal disease (LMD) significantly affects the prognosis and treatment of pediatric patients with medulloblastoma or primitive neuroectodermal tumor (PNET). Examination of CSF for malignant cells, detection of LMD on spinal magnetic resonance imaging (MRI), or both are the methods routinely used to diagnose LMD. A recent study suggested 100% correlation between CSF and MRI findings in children with medulloblastoma. To determine the validity of this hypothesis, we compared the rate of detection of LMD between concurrent lumbar CSF cytology and spinal MRI performed at diagnosis in patients with medulloblastoma or PNET. Patients and Methods: As a part of diagnostic staging, 106 consecutive patients newly diagnosed with medulloblastoma or PNET were evaluated with concurrent lumbar CSF cytology and spinal MRI. CSF cytology was examined for the presence of malignant cells and spinal MRI was reviewed independently for the presence of LMD. Results: Thirty-four patients (32%) were diagnosed with LMD based on CSF cytology, spinal MRI, or both. There were 21 discordant results. Nine patients (8.5%) with positive MRI had negative CSF cytology. Twelve patients (11.3%) with positive CSF cytology had negative MRIs. The exact 95% upper bounds on the proportion of patients with LMD whose disease would have gone undetected using either CSF cytology or MRI as the only diagnostic modality were calculated at 14.4% and 17.7%, respectively. Conclusion: With the use of either CSF cytology or spinal MRI alone, LMD would be missed in up to 14% to 18% of patients with medulloblastoma or PNET. Thus, both CSF cytology and spinal MRI should routinely be used to diagnose LMD in patients with medulloblastoma or PNET.

Original languageEnglish (US)
Pages (from-to)3234-3237
Number of pages4
JournalJournal of Clinical Oncology
Volume17
Issue number10
DOIs
StatePublished - Jan 1 1999

Fingerprint

Primitive Neuroectodermal Tumors
Medulloblastoma
Cell Biology
Magnetic Resonance Imaging
Pediatrics
Spinal Diseases

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Comparison of CSF cytology and spinal magnetic resonance imaging in the detection of leptomeningeal disease in pediatric medulloblastoma or primitive neuroectodermal tumor. / Fouladi, Maryam; Gajjar, Amar; Boyett, James M.; Walter, Andrew W.; Thompson, Stephen J.; Merchant, Thomas E.; Jenkins, Jesse J.; Langston, James W.; Liu, Aiyi; Kun, Larry E.; Heideman, Richard L.

In: Journal of Clinical Oncology, Vol. 17, No. 10, 01.01.1999, p. 3234-3237.

Research output: Contribution to journalArticle

Fouladi, M, Gajjar, A, Boyett, JM, Walter, AW, Thompson, SJ, Merchant, TE, Jenkins, JJ, Langston, JW, Liu, A, Kun, LE & Heideman, RL 1999, 'Comparison of CSF cytology and spinal magnetic resonance imaging in the detection of leptomeningeal disease in pediatric medulloblastoma or primitive neuroectodermal tumor', Journal of Clinical Oncology, vol. 17, no. 10, pp. 3234-3237. https://doi.org/10.1200/JCO.1999.17.10.3234
Fouladi, Maryam ; Gajjar, Amar ; Boyett, James M. ; Walter, Andrew W. ; Thompson, Stephen J. ; Merchant, Thomas E. ; Jenkins, Jesse J. ; Langston, James W. ; Liu, Aiyi ; Kun, Larry E. ; Heideman, Richard L. / Comparison of CSF cytology and spinal magnetic resonance imaging in the detection of leptomeningeal disease in pediatric medulloblastoma or primitive neuroectodermal tumor. In: Journal of Clinical Oncology. 1999 ; Vol. 17, No. 10. pp. 3234-3237.
@article{816afef1f8474364a9ce4b99da930f7c,
title = "Comparison of CSF cytology and spinal magnetic resonance imaging in the detection of leptomeningeal disease in pediatric medulloblastoma or primitive neuroectodermal tumor",
abstract = "Purpose: Leptomeningeal disease (LMD) significantly affects the prognosis and treatment of pediatric patients with medulloblastoma or primitive neuroectodermal tumor (PNET). Examination of CSF for malignant cells, detection of LMD on spinal magnetic resonance imaging (MRI), or both are the methods routinely used to diagnose LMD. A recent study suggested 100{\%} correlation between CSF and MRI findings in children with medulloblastoma. To determine the validity of this hypothesis, we compared the rate of detection of LMD between concurrent lumbar CSF cytology and spinal MRI performed at diagnosis in patients with medulloblastoma or PNET. Patients and Methods: As a part of diagnostic staging, 106 consecutive patients newly diagnosed with medulloblastoma or PNET were evaluated with concurrent lumbar CSF cytology and spinal MRI. CSF cytology was examined for the presence of malignant cells and spinal MRI was reviewed independently for the presence of LMD. Results: Thirty-four patients (32{\%}) were diagnosed with LMD based on CSF cytology, spinal MRI, or both. There were 21 discordant results. Nine patients (8.5{\%}) with positive MRI had negative CSF cytology. Twelve patients (11.3{\%}) with positive CSF cytology had negative MRIs. The exact 95{\%} upper bounds on the proportion of patients with LMD whose disease would have gone undetected using either CSF cytology or MRI as the only diagnostic modality were calculated at 14.4{\%} and 17.7{\%}, respectively. Conclusion: With the use of either CSF cytology or spinal MRI alone, LMD would be missed in up to 14{\%} to 18{\%} of patients with medulloblastoma or PNET. Thus, both CSF cytology and spinal MRI should routinely be used to diagnose LMD in patients with medulloblastoma or PNET.",
author = "Maryam Fouladi and Amar Gajjar and Boyett, {James M.} and Walter, {Andrew W.} and Thompson, {Stephen J.} and Merchant, {Thomas E.} and Jenkins, {Jesse J.} and Langston, {James W.} and Aiyi Liu and Kun, {Larry E.} and Heideman, {Richard L.}",
year = "1999",
month = "1",
day = "1",
doi = "10.1200/JCO.1999.17.10.3234",
language = "English (US)",
volume = "17",
pages = "3234--3237",
journal = "Journal of Clinical Oncology",
issn = "0732-183X",
publisher = "American Society of Clinical Oncology",
number = "10",

}

TY - JOUR

T1 - Comparison of CSF cytology and spinal magnetic resonance imaging in the detection of leptomeningeal disease in pediatric medulloblastoma or primitive neuroectodermal tumor

AU - Fouladi, Maryam

AU - Gajjar, Amar

AU - Boyett, James M.

AU - Walter, Andrew W.

AU - Thompson, Stephen J.

AU - Merchant, Thomas E.

AU - Jenkins, Jesse J.

AU - Langston, James W.

AU - Liu, Aiyi

AU - Kun, Larry E.

AU - Heideman, Richard L.

PY - 1999/1/1

Y1 - 1999/1/1

N2 - Purpose: Leptomeningeal disease (LMD) significantly affects the prognosis and treatment of pediatric patients with medulloblastoma or primitive neuroectodermal tumor (PNET). Examination of CSF for malignant cells, detection of LMD on spinal magnetic resonance imaging (MRI), or both are the methods routinely used to diagnose LMD. A recent study suggested 100% correlation between CSF and MRI findings in children with medulloblastoma. To determine the validity of this hypothesis, we compared the rate of detection of LMD between concurrent lumbar CSF cytology and spinal MRI performed at diagnosis in patients with medulloblastoma or PNET. Patients and Methods: As a part of diagnostic staging, 106 consecutive patients newly diagnosed with medulloblastoma or PNET were evaluated with concurrent lumbar CSF cytology and spinal MRI. CSF cytology was examined for the presence of malignant cells and spinal MRI was reviewed independently for the presence of LMD. Results: Thirty-four patients (32%) were diagnosed with LMD based on CSF cytology, spinal MRI, or both. There were 21 discordant results. Nine patients (8.5%) with positive MRI had negative CSF cytology. Twelve patients (11.3%) with positive CSF cytology had negative MRIs. The exact 95% upper bounds on the proportion of patients with LMD whose disease would have gone undetected using either CSF cytology or MRI as the only diagnostic modality were calculated at 14.4% and 17.7%, respectively. Conclusion: With the use of either CSF cytology or spinal MRI alone, LMD would be missed in up to 14% to 18% of patients with medulloblastoma or PNET. Thus, both CSF cytology and spinal MRI should routinely be used to diagnose LMD in patients with medulloblastoma or PNET.

AB - Purpose: Leptomeningeal disease (LMD) significantly affects the prognosis and treatment of pediatric patients with medulloblastoma or primitive neuroectodermal tumor (PNET). Examination of CSF for malignant cells, detection of LMD on spinal magnetic resonance imaging (MRI), or both are the methods routinely used to diagnose LMD. A recent study suggested 100% correlation between CSF and MRI findings in children with medulloblastoma. To determine the validity of this hypothesis, we compared the rate of detection of LMD between concurrent lumbar CSF cytology and spinal MRI performed at diagnosis in patients with medulloblastoma or PNET. Patients and Methods: As a part of diagnostic staging, 106 consecutive patients newly diagnosed with medulloblastoma or PNET were evaluated with concurrent lumbar CSF cytology and spinal MRI. CSF cytology was examined for the presence of malignant cells and spinal MRI was reviewed independently for the presence of LMD. Results: Thirty-four patients (32%) were diagnosed with LMD based on CSF cytology, spinal MRI, or both. There were 21 discordant results. Nine patients (8.5%) with positive MRI had negative CSF cytology. Twelve patients (11.3%) with positive CSF cytology had negative MRIs. The exact 95% upper bounds on the proportion of patients with LMD whose disease would have gone undetected using either CSF cytology or MRI as the only diagnostic modality were calculated at 14.4% and 17.7%, respectively. Conclusion: With the use of either CSF cytology or spinal MRI alone, LMD would be missed in up to 14% to 18% of patients with medulloblastoma or PNET. Thus, both CSF cytology and spinal MRI should routinely be used to diagnose LMD in patients with medulloblastoma or PNET.

UR - http://www.scopus.com/inward/record.url?scp=0032886935&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032886935&partnerID=8YFLogxK

U2 - 10.1200/JCO.1999.17.10.3234

DO - 10.1200/JCO.1999.17.10.3234

M3 - Article

C2 - 10506624

AN - SCOPUS:0032886935

VL - 17

SP - 3234

EP - 3237

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

SN - 0732-183X

IS - 10

ER -