Comparison of Tumor Enucleation and Standard Partial Nephrectomy According to Trifecta Outcomes: A Multicenter Study by the Turkish Academy of Urology, Uro-Oncology Working Group

Meftun Culpan, Gokhan Atis, Oner Sanli, Yasar Bozkurt, Ali Fuat Atmaca, Bülent Semerci, Cemil Kutsal, Abdullah Erdem Canda, Fatih Akbulut, Volkan Tugcu, Ugur Boylu, Sakip Erturhan, Orhan Koca, Ferhat Ateş, Fikret Halis, Sedat Soyupek, Burak Turna, Sedat Cakmak, Selcuk Sahin, Selcuk ErdemAsif Yildirim

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: We aimed to evaluate the impact of the resection technique (tumor enucleation (TE) or standard partial nephrectomy (SPN)) on trifecta outcomes in patients having undergone partial nephrectomy (PN). Materials and Methods: We retrospectively analyzed the clinical and pathologic parameters in patients with localized renal cell carcinoma (pT1–2N0M0) who had undergone PN between January 2001–December 2018 at one of 15 different tertiary referral centers. Multivariable logistic regression analysis was applied to investigate independent predictors of trifecta failure, decreased postoperative renal functions (decreased estimated glomerular filtration rate (eGFR) > 10%), perioperative complications (Clavien–Dindo > 1), and positive surgical margins. Results: A total of 1070 patients with a mean age 56.11 ± 11.88 years were included in our study. PN was performed with TE in 848 (79.25%) and SPN in 222 (20.75%) patients. Trifecta failure rate was 56.2% for TE and 64.4% for SPN (p = 0.028). On multivariable analysis, TE was associated with less trifecta failure (p = 0.025) and eGFR decrease >10% rates (p = 0.024). On the other hand, there was no statistically significant difference between TE and SPN according to positive surgical margins (p = 0.450) and complication > Clavien-Dindo grade 1 (p = 0.888) rates. The only independent predictive factor for complications > Clavien–Dindo 1 was the Charlson comorbidity index (CCI) (p = 0.001). Conclusion: TE is associated with less trifecta failure than SPN. This result is mainly due to better preservation of renal function with TE.

Original languageEnglish (US)
JournalJournal of Investigative Surgery
DOIs
StateAccepted/In press - 2021
Externally publishedYes

Keywords

  • Complication
  • enucleation
  • partial nephrectomy
  • RCC
  • trifecta

ASJC Scopus subject areas

  • Surgery

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