TY - JOUR
T1 - Concentrations of erythromycin in serum and tonsil
T2 - comparison of the estolate and ethyl succinate suspensions
AU - Lietman, Paul S.
AU - Ginsburg, Charles M.
AU - McCracken, George H.
AU - Culbertson, M. C.
N1 - Funding Information:
From the Departments of Pediatrics and Otolaryngology, University of Texas Southwestern Medical School. Supported in part by a grant from Lilly Research Laboratories. *Reprint address: Department of Pediatrics, Universi(v of Texas, Southwestern Medical School, 5323 Harry Hines Blvd., Dallas, TX 75235.
PY - 1976/12
Y1 - 1976/12
N2 - Concentrations of erythromycin were measured in serum and tonsil from children who had received either the estolate or ethyl succinate suspension before surgery. The in vitro assay measured total erythromycin activity against a group A beta hemolytic streptococcus. Levels of erythromycin in serum and tonsil after single and multiple doses of the estolate were significantly higher than those after administration of the ethyl succinate. The therapeutic implications of these findings are unknown.
AB - Concentrations of erythromycin were measured in serum and tonsil from children who had received either the estolate or ethyl succinate suspension before surgery. The in vitro assay measured total erythromycin activity against a group A beta hemolytic streptococcus. Levels of erythromycin in serum and tonsil after single and multiple doses of the estolate were significantly higher than those after administration of the ethyl succinate. The therapeutic implications of these findings are unknown.
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U2 - 10.1016/S0022-3476(76)80622-1
DO - 10.1016/S0022-3476(76)80622-1
M3 - Article
C2 - 792404
AN - SCOPUS:0017057679
SN - 0022-3476
VL - 89
SP - 1011
EP - 1013
JO - The Journal of pediatrics
JF - The Journal of pediatrics
IS - 6
ER -