Congenital chromosome breakage clusters within giemsa-light bands and identifies sites of chromatin instability

P. Koduru, R. Chaganti

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Analysis of the distribution of published chromosome breaks in cells with constitutional chromosome aberrations showed a Non-random distribution of breaks among chromosomes and chromosome regions. A significant amount of breakage occurred at Giemsa-negative bands. In addition, chromosome sites associated with a number of fragile sites and cellular oncogene sites were affected Non-randomly. The data are consistent with the hypothesis that chromosome breakage occurs in somatic or germ cells as a result of recombinational errors involving actively transcribing chromatin regions or regions of unstable DNA sequence structure placed in proximity during interphase.

Original languageEnglish (US)
Pages (from-to)269-274
Number of pages6
JournalCytogenetic and Genome Research
Volume49
Issue number4
DOIs
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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