Congenital chromosome breakage clusters within Giemsa-light bands and identifies sites of chromatin instability

P. Koduru, R. Chaganti

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Analysis of the distribution of published chromosome breaks in cells with constitutional chromosome aberrations showed a nonrandom distribution of breaks among chromosomes and chromosome regions. A significant amount of breakage occurred at Giemsa-negative bands. In addition, chromosome sites associated with a number of fragile sites and cellular oncogene sites were affected nonrandomly. The data are consistent with the hypothesis that chromosome breakage occurs in somatic or germ cells as a result of recombinational errors involving actively transcribing chromatin regions or regions of unstable DNA sequence structure placed in proximity during interphase.

Original languageEnglish (US)
Pages (from-to)269-274
Number of pages6
JournalCytogenetics and Cell Genetics
Volume49
Issue number4
StatePublished - 1988

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Chromosome Breakage
Chromatin
Unstable DNA Sequences
Chromosomes
Interphase
Oncogenes
Germ Cells
Chromosome Aberrations

ASJC Scopus subject areas

  • Cell Biology
  • Genetics

Cite this

Congenital chromosome breakage clusters within Giemsa-light bands and identifies sites of chromatin instability. / Koduru, P.; Chaganti, R.

In: Cytogenetics and Cell Genetics, Vol. 49, No. 4, 1988, p. 269-274.

Research output: Contribution to journalArticle

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