@article{1e6c990f2d384260bad409a63e6a3910,
title = "Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine",
abstract = "The relative contribution of intrinsic genetic factors and extrinsic environmental ones to cancer aetiology and natural history is a lengthy and debated issue. Gene–environment interactions (G x E) arise when the combined presence of both a germline genetic variant and a known environmental factor modulates the risk of disease more than either one alone. A panel of experts discussed our current understanding of cancer aetiology, known examples of G × E interactions in cancer, and the expanded concept of G × E interactions to include somatic cancer mutations and iatrogenic environmental factors such as anti-cancer treatment. Specific genetic polymorphisms and genetic mutations increase susceptibility to certain carcinogens and may be targeted in the near future for prevention and treatment of cancer patients with novel molecularly based therapies. There was general consensus that a better understanding of the complexity and numerosity of G × E interactions, supported by adequate technological, epidemiological, modelling and statistical resources, will further promote our understanding of cancer and lead to novel preventive and therapeutic approaches.",
author = "Michele Carbone and Ivano Amelio and Affar, {El Bachir} and James Brugarolas and Cannon-Albright, {Lisa A.} and Cantley, {Lewis C.} and Cavenee, {Webster K.} and Zhijian Chen and Croce, {Carlo M.} and Andrea, {Alan D{\textquoteright}} and David Gandara and Carlotta Giorgi and Wei Jia and Qing Lan and Mak, {Tak Wah} and Manley, {James L.} and Katsuhiko Mikoshiba and Onuchic, {Jose N.} and Pass, {Harvey I.} and Paolo Pinton and Carol Prives and Nathaniel Rothman and Sebti, {Said M.} and James Turkson and Xifeng Wu and Haining Yang and Herbert Yu and Gerry Melino",
note = "Funding Information: Acknowledgements The meeting was made possible by a generous donation from the Barry and Virginia Weinman Foundation and by the generous support of the International Association for the Study of Lung Cancer (IASLC). M.C. research is supported by 1R01CA198138-01; DoD Translational Team Award; DoD Idea Award; University of Hawaii Foundation (through the Melohn Endowed Chair in Cancer Biology and Genetics; and through unrestricted donations from Honeywell International and from UNITED-FOR-A-CURE); H.Y research is supported by U01CA214195-01; DoD Translational Team Award; DoD Idea Award; H.I.P. is supported by U01CA214195-01, DoD Translational Team Award; J.B. is supported by P50CA196516, R01CA175754 and RP180192. Publisher Copyright: {\textcopyright} 2018, ADMC Associazione Differenziamento e Morte Cellulare.",
year = "2018",
month = nov,
day = "1",
doi = "10.1038/s41418-018-0213-5",
language = "English (US)",
volume = "25",
pages = "1885--1904",
journal = "Cell Death and Differentiation",
issn = "1350-9047",
publisher = "Nature Publishing Group",
number = "11",
}