Contribution of accelerated degradation to feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol metabolism in the liver

Medicine & Life Sciences

• cholesterol reductase 100%
• 3-hydroxy-3-methylglutaryl-coenzyme A 70%
• Coenzyme A 61%
• Oxidoreductases 49%
• Sterols 33%
• Liver 27%
• Ubiquitination 22%
• Cholesterol 12%
• Transgenic Mice 7%
• Cultured Cells 6%
• Diet 5%
• Lovastatin 5%
• Membranes 4%
• Proteasome Endopeptidase Complex 4%
• Endoplasmic Reticulum 3%
• Atherosclerosis 3%
• Cardiovascular Diseases 3%
• Messenger RNA 2%
• Mutation 2%
• Animals 2%
• Proteins 1%
• Therapeutics 0%

Chemical Compounds

• Coenzyme A 66%
• Cholesterol 48%
• Pharmacological Metabolism 41%
• Lovastatin 6%
• Sterol 4%
• Mammalian Cell 4%
• Mutation 3%
• Protein 1%