Contribution of cholesterol 7α-hydroxylase to the regulation of lipoprotein metabolism

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26 Scopus citations

Abstract

Clinical studies have clearly established a relationship between bile acid synthesis and plasma LDL-cholesterol concentrations. Interruption of the enterohepatic circulation of bile acids leads to increased bile acid synthesis and a reduction in plasma LDL-cholesterol concentrations. New studies indicate that genetic variation in cholesterol 7α-hydroxylase activity accounts for a significant fraction of the inter-individual variation in plasma LDL-cholesterol concentrations in the general population, and a specific CYP7A1 allele associated with increased plasma LDL-cholesterol concentrations has been identified. Studies in which cholesterol 7α-hydroxylase was transiently overexpressed in hamsters and mice indicate that direct manipulation of cholesterol 7α-hydroxylase leads to changes in plasma LDL-cholesterol concentrations. Interestingly, targeted inactivation of the gene encoding cholesterol 7α-hydroxylase does not lead to increased plasma LDL-cholesterol concentrations in mice.

Original languageEnglish (US)
Pages (from-to)303-307
Number of pages5
JournalCurrent opinion in lipidology
Volume10
Issue number4
DOIs
StatePublished - 1999

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Genetics
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

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