Control of cardiac development by an evolutionarily conserved transcriptional network

Richard M. Cripps, Eric N. Olson

Research output: Contribution to journalReview articlepeer-review

251 Scopus citations

Abstract

Formation of the heart is dependent on an intricate cascade of developmental decisions. Analysis of the molecules and mechanisms involved in the specification of cardiac cell fates, differentiation and diversification of cardiac muscle cells, and morphogenesis and patterning of different cardiac cell types has revealed an evolutionarily conserved network of signaling pathways and transcription factors that underlies these processes. The regulatory network that controls the formation of the primitive heart in fruit flies has been elaborated upon to form the complex multichambered heart of mammals. We compare and contrast the mechanisms involved in heart formation in fruit flies and mammals in the context of a network of transcriptional interactions and point to unresolved questions for the future.

Original languageEnglish (US)
Pages (from-to)14-28
Number of pages15
JournalDevelopmental Biology
Volume246
Issue number1
DOIs
StatePublished - Jun 1 2002

Keywords

  • Cardiogenesis
  • Dorsal vessel
  • Drosophila
  • Gene network
  • Heart
  • Review
  • Transcription factor
  • Transcription network

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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