Controlled release of therapeutics using interpenetrating polymeric networks

Tejraj M. Aminabhavi, Mallikarjuna N. Nadagouda, Uttam A. More, Shrinivas D. Joshi, Venkatrao H. Kulkarni, Malleshappa N. Noolvi, Padmakar V. Kulkarni

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations

Abstract

Introduction: The ever-increasing developments in pharmaceutical formulations have led to the widespread use of biodegradable polymers in various forms and configurations. In particular, interpenetrating network (IPN) and semi-IPN polymer structures that are capable of releasing drugs in a controlled manner have gained much wider importance in recent years.Areas covered: Recently, IPNs and semi-IPNs have emerged as innovative materials of choice in controlled release (CR) of drugs as the release from these systems depends on pH of the media and temperature in addition to the nature of the system. These networks can be prepared as smart hydrogels following chemical or physical crosslinking methods to show remarkable drug release patterns compared to single polymer systems.Expert opinion: A large number of IPNs and semi-IPNs have been reported in the literature. The present review is focused on the preparation methods and their CR properties with reference to anticancer, anti-asthmatic, antibiotic, anti-inflammatory, anti-tuberculosis and antihypertensive drugs, as majority of these drugs have been reported to be the ideal choices for using IPNs and semi-IPNs.

Original languageEnglish (US)
Pages (from-to)669-688
Number of pages20
JournalExpert Opinion on Drug Delivery
Volume12
Issue number4
DOIs
StatePublished - Apr 1 2015

Keywords

  • Controlled release
  • Hydrogels
  • Interpenetrating networks
  • Microspheres
  • Semi-interpenetrating networks

ASJC Scopus subject areas

  • Pharmaceutical Science

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