Convergent diversity-oriented synthesis of small-molecule hybrids

Chuo Chen, Xiaodong Li, Christopher S. Neumann, Michael M C Lo, Stuart L. Schreiber

Research output: Contribution to journalArticlepeer-review

82 Scopus citations

Abstract

(Chemical Equation Presented) Complex small-molecule libraries were constructed by a convergent approach with a short linear sequence: a 480-membered bridged-piperidine/fused-pyrrolidine hybrid library IV and a 384-membered spirocyclic-oxindole/fused-pyrrolidine hybrid library V from the sub-library II and the sublibraries I and III, respectively. II = R II-COOH.

Original languageEnglish (US)
Pages (from-to)2249-2252
Number of pages4
JournalAngewandte Chemie - International Edition
Volume44
Issue number15
DOIs
StatePublished - Apr 8 2005

Keywords

  • Convergent synthesis
  • Diversity-oriented synthesis
  • Polycycles
  • Small-molecule hybrids
  • Solid-phase synthesis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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