Coordinate regulation/localization of the carbohydrate responsive binding protein (ChREBP) by two nuclear export signal sites: Discovery of a new leucine-rich nuclear export signal site

Masashi Fukasawa, Qing Ge, R. Max Wynn, Seiji Ishii, Kosaku Uyeda

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Carbohydrate response element binding protein (ChREBP) is responsible for conversion of dietary carbohydrate to storage fat in liver by coordinating expression of the enzymes that channel glycolytic pyruvate into lipogenesis. The activation of ChREBP in response to high glucose is nuclear localization and transcription, and the inactivation of ChREBP under low glucose involves export from the nucleus to the cytosol. Here we report a new nuclear export signal site ("NES1") of ChREBP. Together these signals provide ChREBP with two NES sequences, both the previously reported NES2 and now the new NES1 coordinate to interact together with CRM1 (exportin) for nuclear export of the carbohydrate response element binding protein.

Original languageEnglish (US)
Pages (from-to)1166-1169
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume391
Issue number2
DOIs
StatePublished - Jan 8 2010

Keywords

  • Carbohydrate responsive element binding protein
  • Glucose signals and 14-3-3
  • Lipogenesis
  • Nuclear import/export signal sites
  • Transcription factor

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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