COPD: A dust-induced disease?

Carlos E. Girod, Talmadge E. King

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Various reports have demonstrated the importance of small airway inflammation in the development of airflow limitation and progression of COPD. This hypothesis proposes that the pathogenesis of COPD mirrors a chronic inhalational dust-induced disease. The putative inorganic dust in cigarette smoke is aluminum silicate or kaolinite, a common component of clay soils. Kaolinite has been recovered in the alveolar macrophages of smokers and has been reported as a constituent of tobacco products. The origin of kaolinite in tobacco products remains unknown, and possible potential sources are proposed. On inhalation, kaolinite deposition in the distal lung may promote macrophage accumulation within the terminal airways leading to a respiratory bronchiolitis. In the susceptible smoker, important genetic, environmental, immunologic, and mechanical factors interact and modulate this small airway inflammation, ultimately leading to the pathologic lesion of emphysema. Further studies into the effects of kaolinite on macrophage function and the subsequent development of respiratory bronchiolitis could lead to prevention of COPD at its precursor lesion.

Original languageEnglish (US)
Pages (from-to)3055-3064
Number of pages10
JournalChest
Volume128
Issue number4
DOIs
StatePublished - Oct 2005

Fingerprint

Kaolin
Dust
Chronic Obstructive Pulmonary Disease
Tobacco Products
Bronchiolitis
Aluminum Silicates
Macrophages
Inflammation
Emphysema
Alveolar Macrophages
Immunologic Factors
Smoke
Inhalation
Soil
Lung

Keywords

  • Alveolar macrophages
  • Bronchiolitis
  • COPD, etiology
  • Emphysema, etiology
  • Kaolin
  • Smoking

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

COPD : A dust-induced disease? / Girod, Carlos E.; King, Talmadge E.

In: Chest, Vol. 128, No. 4, 10.2005, p. 3055-3064.

Research output: Contribution to journalArticle

Girod, CE & King, TE 2005, 'COPD: A dust-induced disease?', Chest, vol. 128, no. 4, pp. 3055-3064. https://doi.org/10.1378/chest.128.4.3055
Girod, Carlos E. ; King, Talmadge E. / COPD : A dust-induced disease?. In: Chest. 2005 ; Vol. 128, No. 4. pp. 3055-3064.
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