COPD is associated with production of autoantibodies to a broad spectrum of self-antigens, correlative with disease phenotype

Thomas A. Packard, Quan Z. Li, Gregory P. Cosgrove, Russell P. Bowler, John C. Cambier

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The role of autoimmune pathology in development and progression of chronic obstructive pulmonary disease (COPD) is becoming increasingly appreciated. In this study, we identified serum autoantibody reactivities associated with chronic bronchitis or emphysema, as well as systemic autoimmunity and associated lung disease. Using autoantigen array analysis, we demonstrated that COPD patients produce autoantibodies reactive to a broad spectrum of self-antigens. Further, the level and reactivities of these antibodies, or autoantibody profile, correlated with disease phenotype. Patients with emphysema produced autoantibodies of higher titer and reactive to an increased number of array antigens. Strikingly, the autoantibody reactivities observed in emphysema were increased over those detected in rheumatoid arthritis patients, and included similar reactivities to those associated with lupus. These findings raise the possibility that autoantibody profiles may be used to determine COPD risk, as well as provide a diagnostic and prognostic tool. They shed light on the heterogeneity of autoantibody reactivities associated with COPD phenotype and could be of use in the personalization of medical treatment, including determining and monitoring therapeutic interventions.

Original languageEnglish (US)
Pages (from-to)48-57
Number of pages10
JournalImmunologic Research
Volume55
Issue number1-3
DOIs
StatePublished - Mar 2013

Fingerprint

Autoantigens
Autoantibodies
Chronic Obstructive Pulmonary Disease
Phenotype
Emphysema
Chronic Bronchitis
Autoimmunity
Lung Diseases
Rheumatoid Arthritis
Pathology
Antigens
Antibodies
Therapeutics
Serum

Keywords

  • Antigen array
  • Autoantibodies
  • COPD
  • ILD
  • RA
  • SLE

ASJC Scopus subject areas

  • Immunology

Cite this

COPD is associated with production of autoantibodies to a broad spectrum of self-antigens, correlative with disease phenotype. / Packard, Thomas A.; Li, Quan Z.; Cosgrove, Gregory P.; Bowler, Russell P.; Cambier, John C.

In: Immunologic Research, Vol. 55, No. 1-3, 03.2013, p. 48-57.

Research output: Contribution to journalArticle

Packard, Thomas A. ; Li, Quan Z. ; Cosgrove, Gregory P. ; Bowler, Russell P. ; Cambier, John C. / COPD is associated with production of autoantibodies to a broad spectrum of self-antigens, correlative with disease phenotype. In: Immunologic Research. 2013 ; Vol. 55, No. 1-3. pp. 48-57.
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