Corneal Deturgescence after Descemet Stripping Automated Endothelial Keratoplasty Evaluated by Visante Anterior Segment Optical Coherence Tomography

Mario A. Di Pascuale, Pawan Prasher, Charlie Schlecte, Mark Arey, Robert W Bowman, Harrison D Cavanagh, James P McCulley, Venkateswara Mootha

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Purpose: To evaluate postoperative corneal deturgescence after Descemet stripping endothelial keratoplasty (DSAEK) using the Visante anterior segment optical coherence tomography (OCT) system (Carl Zeiss Meditec Inc, Dublin, California, USA). Design: Retrospective case series. Methods: We included 21 eyes (9 males and 12 females; mean age ± standard deviation, 76.3 ± 12 years). The Visante OCT system was used to determine the central and peripheral endothelial keratoplasty graft thickness and total central and peripheral corneal thickness. Results: Central graft thickness decreased from the first day (243.3 ± 92 μm) to the last visit (147.8 ± 44 μm; P = .0001). The rate of central graft thinning slowed during the following intervals: during the first week (47 μm), at 1 week to 1 month (40 μm), and at 1 to 6 months (25 μm), with a mild increase at 6 to 9 months (5 μm). Peripheral graft thickness continued to decrease from postoperative day 1 (318.5 ± 99 μm) to the last visit (196.7 ± 50 μm; P = .0001). There was a decrease in total central corneal thickness from day 1 (903.8 ± 179 μm) to the last visit (671 ± 93 μm; P = .0001). All patients were imaged with the Visante OCT at the first 4 defined postoperative intervals; however, only 9 eyes were imaged at the last interval of 6 to 9 months. Conclusions: After DSAEK, there is a greater thinning of the central graft compared with the peripheral graft. The central cornea thickness decreases and peripheral corneal thickness increases. Central corneal graft deturgescence stabilizes by 6 months after surgery.

Original languageEnglish (US)
Pages (from-to)32-37.e1
JournalAmerican journal of ophthalmology
Issue number1
StatePublished - Jul 2009


ASJC Scopus subject areas

  • Ophthalmology

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