TY - JOUR
T1 - Corneal Deturgescence after Descemet Stripping Automated Endothelial Keratoplasty Evaluated by Visante Anterior Segment Optical Coherence Tomography
AU - Di Pascuale, Mario A.
AU - Prasher, Pawan
AU - Schlecte, Charlie
AU - Arey, Mark
AU - Bowman, Robert W
AU - Cavanagh, Harrison D
AU - McCulley, James P
AU - Mootha, Venkateswara
N1 - Funding Information:
This study was supported in part by an unrestricted grant from Research to Prevent Blindness, Inc, New York, New York. The authors indicate no financial conflict of interest. Involved in design and conduct of study (M.A.D.P., V.V.M.); collection of data (M.A.D.P., P.P., M.A., C.S.); management, analysis, and interpretation of data (M.A.D.P., V.V.M.); and preparation (M.A.D.P., R.W.B., H.D.C., J.P.M., V.V.M.), review (M.A.D.P., P.P., C.S., M.A., R.W.B., H.D.C., J.P.M., V.V.M.), and approval of the manuscript (M.A.D.P., P.P., C.S., M.A., R.W.B., H.D.C., J.P.M., V.V.M.). This study was approved by the Institutional Review Board of the University of Texas Southwestern Medical Center and followed the tenets Declaration of Helsinki. This study is registered at http://www.clinicaltrials.gov under clinical trial no. NCT00744796 .
PY - 2009/7
Y1 - 2009/7
N2 - Purpose: To evaluate postoperative corneal deturgescence after Descemet stripping endothelial keratoplasty (DSAEK) using the Visante anterior segment optical coherence tomography (OCT) system (Carl Zeiss Meditec Inc, Dublin, California, USA). Design: Retrospective case series. Methods: We included 21 eyes (9 males and 12 females; mean age ± standard deviation, 76.3 ± 12 years). The Visante OCT system was used to determine the central and peripheral endothelial keratoplasty graft thickness and total central and peripheral corneal thickness. Results: Central graft thickness decreased from the first day (243.3 ± 92 μm) to the last visit (147.8 ± 44 μm; P = .0001). The rate of central graft thinning slowed during the following intervals: during the first week (47 μm), at 1 week to 1 month (40 μm), and at 1 to 6 months (25 μm), with a mild increase at 6 to 9 months (5 μm). Peripheral graft thickness continued to decrease from postoperative day 1 (318.5 ± 99 μm) to the last visit (196.7 ± 50 μm; P = .0001). There was a decrease in total central corneal thickness from day 1 (903.8 ± 179 μm) to the last visit (671 ± 93 μm; P = .0001). All patients were imaged with the Visante OCT at the first 4 defined postoperative intervals; however, only 9 eyes were imaged at the last interval of 6 to 9 months. Conclusions: After DSAEK, there is a greater thinning of the central graft compared with the peripheral graft. The central cornea thickness decreases and peripheral corneal thickness increases. Central corneal graft deturgescence stabilizes by 6 months after surgery.
AB - Purpose: To evaluate postoperative corneal deturgescence after Descemet stripping endothelial keratoplasty (DSAEK) using the Visante anterior segment optical coherence tomography (OCT) system (Carl Zeiss Meditec Inc, Dublin, California, USA). Design: Retrospective case series. Methods: We included 21 eyes (9 males and 12 females; mean age ± standard deviation, 76.3 ± 12 years). The Visante OCT system was used to determine the central and peripheral endothelial keratoplasty graft thickness and total central and peripheral corneal thickness. Results: Central graft thickness decreased from the first day (243.3 ± 92 μm) to the last visit (147.8 ± 44 μm; P = .0001). The rate of central graft thinning slowed during the following intervals: during the first week (47 μm), at 1 week to 1 month (40 μm), and at 1 to 6 months (25 μm), with a mild increase at 6 to 9 months (5 μm). Peripheral graft thickness continued to decrease from postoperative day 1 (318.5 ± 99 μm) to the last visit (196.7 ± 50 μm; P = .0001). There was a decrease in total central corneal thickness from day 1 (903.8 ± 179 μm) to the last visit (671 ± 93 μm; P = .0001). All patients were imaged with the Visante OCT at the first 4 defined postoperative intervals; however, only 9 eyes were imaged at the last interval of 6 to 9 months. Conclusions: After DSAEK, there is a greater thinning of the central graft compared with the peripheral graft. The central cornea thickness decreases and peripheral corneal thickness increases. Central corneal graft deturgescence stabilizes by 6 months after surgery.
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U2 - 10.1016/j.ajo.2009.01.016
DO - 10.1016/j.ajo.2009.01.016
M3 - Article
C2 - 19327750
AN - SCOPUS:67349154933
SN - 0002-9394
VL - 148
SP - 32-37.e1
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 1
ER -