Coronary reserve and right ventricular function in awake newborn lambs with persistent right ventricular hypertension

J. P. Archie, David E Fixler, J. I E Hoffman

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Right ventricular function curves as measured by right ventricular stroke were normal in all control lambs, whereas three of five lambs with banded pulmonary arteries had relatively flat curves. Left ventricular function was similarly normal in the control group as compared to a near zero slope function curve in the banded group. Regional myocardial blood flow to the septum and right and left ventricles was similar in control and banded lambs. At rest right ventricular coronary vascular resistance was lower in the banded than in the control group and decreased in both groups during both isoproterenol and dextran stress states. In general, both groups had a similar ratio of right to left ventricular oxygen supply to demand ratio. These results show first that there is minimal, if any, biventricular functional reserve in lambs with persistent right ventricular hypertension, and second, that there is substantial coronary vascular reserve in both normal and banded groups. Although both right and left ventricular function are impaired in neonatal lambs with persistent right ventricular hypertension, the etiology is unclear. The authors have demonstrated right ventricular coronary vascular reserve in this group; however, the authors did not test for further reserve in the dextran stress state, and therefore cannot be certain that coronary blood flow was not maximal in the dextran state and hence ventricular function impaired by inadequate oxygen supply.

Original languageEnglish (US)
Pages (from-to)867-870
Number of pages4
JournalPediatric Research
Volume11
Issue number7
StatePublished - 1977

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Right Ventricular Function
Dextrans
Hypertension
Left Ventricular Function
Heart Ventricles
Blood Vessels
Oxygen
Control Groups
Ventricular Function
Regional Blood Flow
Isoproterenol
Vascular Resistance
Pulmonary Artery
Stroke

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Coronary reserve and right ventricular function in awake newborn lambs with persistent right ventricular hypertension. / Archie, J. P.; Fixler, David E; Hoffman, J. I E.

In: Pediatric Research, Vol. 11, No. 7, 1977, p. 867-870.

Research output: Contribution to journalArticle

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AB - Right ventricular function curves as measured by right ventricular stroke were normal in all control lambs, whereas three of five lambs with banded pulmonary arteries had relatively flat curves. Left ventricular function was similarly normal in the control group as compared to a near zero slope function curve in the banded group. Regional myocardial blood flow to the septum and right and left ventricles was similar in control and banded lambs. At rest right ventricular coronary vascular resistance was lower in the banded than in the control group and decreased in both groups during both isoproterenol and dextran stress states. In general, both groups had a similar ratio of right to left ventricular oxygen supply to demand ratio. These results show first that there is minimal, if any, biventricular functional reserve in lambs with persistent right ventricular hypertension, and second, that there is substantial coronary vascular reserve in both normal and banded groups. Although both right and left ventricular function are impaired in neonatal lambs with persistent right ventricular hypertension, the etiology is unclear. The authors have demonstrated right ventricular coronary vascular reserve in this group; however, the authors did not test for further reserve in the dextran stress state, and therefore cannot be certain that coronary blood flow was not maximal in the dextran state and hence ventricular function impaired by inadequate oxygen supply.

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