Correlating function and imaging measures of the medial longitudinal fasciculus

Ken Sakaie, Masaya Takahashi, Gina Remington, Xiaofeng Wang, Amy Conger, Darrel Conger, Ivan Dimitrov, Stephen Jones, Ashley Frohman, Teresa Frohman, Koji Sagiyama, Osamu Togao, Robert J. Fox, Elliot Frohman

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To test the validity of diffusion tensor imaging (DTI) measures of tissue injury by examining such measures in a white matter structure with well-defined function, the medial longitudinal fasciculus (MLF). Injury to the MLF underlies internuclear ophthalmoparesis (INO). Methods: 40 MS patients with chronic INO and 15 healthy controls were examined under an IRB-approved protocol. Tissue integrity of the MLF was characterized by DTI parameters: longitudinal diffusivity (LD), transverse diffusivity (TD), mean diffusivity (MD) and fractional anisotropy (FA). Severity of INO was quantified by infrared oculography to measure versional disconjugacy index (VDI). Results: LD was significantly lower in patients than in controls in the medulla-pons region of the MLF (p <0.03). FA was also lower in patients in the same region (p <0.0004). LD of the medullapons region correlated with VDI (R = -0.28, p <0.05) as did FA in the midbrain section (R = 0.31, p <0.02). Conclusions: This study demonstrates that DTI measures of brain tissue injury can detect injury to a functionally relevant white matter pathway, and that such measures correlate with clinically accepted evaluation indices for INO. The results validate DTI as a useful imaging measure of tissue integrity.

Original languageEnglish (US)
Article numbere0147863
JournalPLoS One
Volume11
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

Ophthalmoplegia
Diffusion Tensor Imaging
Diffusion tensor imaging
diffusivity
Anisotropy
image analysis
Imaging techniques
Tissue
Wounds and Injuries
Pons
Research Ethics Committees
brain
Mesencephalon
Brain Injuries
Brain
Infrared radiation
tissues
testing
White Matter

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Correlating function and imaging measures of the medial longitudinal fasciculus. / Sakaie, Ken; Takahashi, Masaya; Remington, Gina; Wang, Xiaofeng; Conger, Amy; Conger, Darrel; Dimitrov, Ivan; Jones, Stephen; Frohman, Ashley; Frohman, Teresa; Sagiyama, Koji; Togao, Osamu; Fox, Robert J.; Frohman, Elliot.

In: PLoS One, Vol. 11, No. 1, e0147863, 01.01.2016.

Research output: Contribution to journalArticle

Sakaie, K, Takahashi, M, Remington, G, Wang, X, Conger, A, Conger, D, Dimitrov, I, Jones, S, Frohman, A, Frohman, T, Sagiyama, K, Togao, O, Fox, RJ & Frohman, E 2016, 'Correlating function and imaging measures of the medial longitudinal fasciculus', PLoS One, vol. 11, no. 1, e0147863. https://doi.org/10.1371/journal.pone.0147863
Sakaie, Ken ; Takahashi, Masaya ; Remington, Gina ; Wang, Xiaofeng ; Conger, Amy ; Conger, Darrel ; Dimitrov, Ivan ; Jones, Stephen ; Frohman, Ashley ; Frohman, Teresa ; Sagiyama, Koji ; Togao, Osamu ; Fox, Robert J. ; Frohman, Elliot. / Correlating function and imaging measures of the medial longitudinal fasciculus. In: PLoS One. 2016 ; Vol. 11, No. 1.
@article{64a009df642b4696829285f03de3f32e,
title = "Correlating function and imaging measures of the medial longitudinal fasciculus",
abstract = "Objective: To test the validity of diffusion tensor imaging (DTI) measures of tissue injury by examining such measures in a white matter structure with well-defined function, the medial longitudinal fasciculus (MLF). Injury to the MLF underlies internuclear ophthalmoparesis (INO). Methods: 40 MS patients with chronic INO and 15 healthy controls were examined under an IRB-approved protocol. Tissue integrity of the MLF was characterized by DTI parameters: longitudinal diffusivity (LD), transverse diffusivity (TD), mean diffusivity (MD) and fractional anisotropy (FA). Severity of INO was quantified by infrared oculography to measure versional disconjugacy index (VDI). Results: LD was significantly lower in patients than in controls in the medulla-pons region of the MLF (p <0.03). FA was also lower in patients in the same region (p <0.0004). LD of the medullapons region correlated with VDI (R = -0.28, p <0.05) as did FA in the midbrain section (R = 0.31, p <0.02). Conclusions: This study demonstrates that DTI measures of brain tissue injury can detect injury to a functionally relevant white matter pathway, and that such measures correlate with clinically accepted evaluation indices for INO. The results validate DTI as a useful imaging measure of tissue integrity.",
author = "Ken Sakaie and Masaya Takahashi and Gina Remington and Xiaofeng Wang and Amy Conger and Darrel Conger and Ivan Dimitrov and Stephen Jones and Ashley Frohman and Teresa Frohman and Koji Sagiyama and Osamu Togao and Fox, {Robert J.} and Elliot Frohman",
year = "2016",
month = "1",
day = "1",
doi = "10.1371/journal.pone.0147863",
language = "English (US)",
volume = "11",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "1",

}

TY - JOUR

T1 - Correlating function and imaging measures of the medial longitudinal fasciculus

AU - Sakaie, Ken

AU - Takahashi, Masaya

AU - Remington, Gina

AU - Wang, Xiaofeng

AU - Conger, Amy

AU - Conger, Darrel

AU - Dimitrov, Ivan

AU - Jones, Stephen

AU - Frohman, Ashley

AU - Frohman, Teresa

AU - Sagiyama, Koji

AU - Togao, Osamu

AU - Fox, Robert J.

AU - Frohman, Elliot

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Objective: To test the validity of diffusion tensor imaging (DTI) measures of tissue injury by examining such measures in a white matter structure with well-defined function, the medial longitudinal fasciculus (MLF). Injury to the MLF underlies internuclear ophthalmoparesis (INO). Methods: 40 MS patients with chronic INO and 15 healthy controls were examined under an IRB-approved protocol. Tissue integrity of the MLF was characterized by DTI parameters: longitudinal diffusivity (LD), transverse diffusivity (TD), mean diffusivity (MD) and fractional anisotropy (FA). Severity of INO was quantified by infrared oculography to measure versional disconjugacy index (VDI). Results: LD was significantly lower in patients than in controls in the medulla-pons region of the MLF (p <0.03). FA was also lower in patients in the same region (p <0.0004). LD of the medullapons region correlated with VDI (R = -0.28, p <0.05) as did FA in the midbrain section (R = 0.31, p <0.02). Conclusions: This study demonstrates that DTI measures of brain tissue injury can detect injury to a functionally relevant white matter pathway, and that such measures correlate with clinically accepted evaluation indices for INO. The results validate DTI as a useful imaging measure of tissue integrity.

AB - Objective: To test the validity of diffusion tensor imaging (DTI) measures of tissue injury by examining such measures in a white matter structure with well-defined function, the medial longitudinal fasciculus (MLF). Injury to the MLF underlies internuclear ophthalmoparesis (INO). Methods: 40 MS patients with chronic INO and 15 healthy controls were examined under an IRB-approved protocol. Tissue integrity of the MLF was characterized by DTI parameters: longitudinal diffusivity (LD), transverse diffusivity (TD), mean diffusivity (MD) and fractional anisotropy (FA). Severity of INO was quantified by infrared oculography to measure versional disconjugacy index (VDI). Results: LD was significantly lower in patients than in controls in the medulla-pons region of the MLF (p <0.03). FA was also lower in patients in the same region (p <0.0004). LD of the medullapons region correlated with VDI (R = -0.28, p <0.05) as did FA in the midbrain section (R = 0.31, p <0.02). Conclusions: This study demonstrates that DTI measures of brain tissue injury can detect injury to a functionally relevant white matter pathway, and that such measures correlate with clinically accepted evaluation indices for INO. The results validate DTI as a useful imaging measure of tissue integrity.

UR - http://www.scopus.com/inward/record.url?scp=84958214773&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84958214773&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0147863

DO - 10.1371/journal.pone.0147863

M3 - Article

C2 - 26800522

AN - SCOPUS:84958214773

VL - 11

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 1

M1 - e0147863

ER -