Correlation of spectroscopy and magnetization transfer imaging in the evaluation of demyelinating lesions and normal appearing white matter in multiple sclerosis

J. F. Hiehle, R. E. Lenkinski, R. I. Grossman, V. Dousset, K. N. Ramer, M. D. Schnall, J. A. Cohen, F. Gonzalez-Scarano

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103 Scopus citations

Abstract

Magnetization transfer imaging (MT) and localized proton spectroscopy (1H‐MRS) were utilized in the evaluation of lesioins (high signal abnormalities on T2‐weighted images) and normal‐appearing white matter (NAWM) in multiple sclerosis (MI). Eleven patients with a clinical diagnosis of MS were independently evaluated with both 1H‐MRS and MT. The magnetization transfer ratio (MTR) of lesions was compared with the relative concentration of Kacetyl‐aspartate (NAA) and a composite peak at 2.1 to 2.6 ppm termed “marker peaks”. The MTR of white matter lesions in the MS patients was markedly decreased (6–34%; normal ≈42%), and correlated well with increase in the marker peaks region (0.94–3.89). There was no correlation between the relative concentration of NAA and MTR. Increased resonance peaks in the 2.1 to 2.6 ppm range and marked decreases in MTR may be a relatively specific indicators of demyelination.

Original languageEnglish (US)
Pages (from-to)285-293
Number of pages9
JournalMagnetic resonance in medicine
Volume32
Issue number3
DOIs
StatePublished - Sep 1994

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Keywords

  • magnetic resonance (MR)
  • magnetization transfer contrast
  • multiple sclerosis
  • proton spectroscopy (H‐MRS)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Hiehle, J. F., Lenkinski, R. E., Grossman, R. I., Dousset, V., Ramer, K. N., Schnall, M. D., Cohen, J. A., & Gonzalez-Scarano, F. (1994). Correlation of spectroscopy and magnetization transfer imaging in the evaluation of demyelinating lesions and normal appearing white matter in multiple sclerosis. Magnetic resonance in medicine, 32(3), 285-293. https://doi.org/10.1002/mrm.1910320303