Correspondence between Resting-State Activity and Brain Gene Expression

Guang Zhong Wang, T. Grant Belgard, Deng Mao, Leslie Chen, Stefano Berto, Todd M. Preuss, Hanzhang Lu, Daniel H. Geschwind, Genevieve Konopka

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The relationship between functional brain activity and gene expression has not been fully explored in the human brain. Here, we identify significant correlations between gene expression in the brain and functional activity by comparing fractional amplitude of low-frequency fluctuations (fALFF) from two independent human fMRI resting-state datasets to regional cortical gene expression from a newly generated RNA-seq dataset and two additional gene expression datasets to obtain robust and reproducible correlations. We find significantly more genes correlated with fALFF than expected by chance and identify specific genes correlated with the imaging signals in multiple expression datasets in the default mode network. Together, these data support a population-level relationship between regional steady-state brain gene expression and resting-state brain activity.

Original languageEnglish (US)
Pages (from-to)659-666
Number of pages8
JournalNeuron
Volume88
Issue number4
DOIs
StatePublished - Nov 18 2015

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Gene Expression
Brain
Genes
Magnetic Resonance Imaging
RNA
Datasets
Population

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Wang, G. Z., Belgard, T. G., Mao, D., Chen, L., Berto, S., Preuss, T. M., ... Konopka, G. (2015). Correspondence between Resting-State Activity and Brain Gene Expression. Neuron, 88(4), 659-666. https://doi.org/10.1016/j.neuron.2015.10.022

Correspondence between Resting-State Activity and Brain Gene Expression. / Wang, Guang Zhong; Belgard, T. Grant; Mao, Deng; Chen, Leslie; Berto, Stefano; Preuss, Todd M.; Lu, Hanzhang; Geschwind, Daniel H.; Konopka, Genevieve.

In: Neuron, Vol. 88, No. 4, 18.11.2015, p. 659-666.

Research output: Contribution to journalArticle

Wang, GZ, Belgard, TG, Mao, D, Chen, L, Berto, S, Preuss, TM, Lu, H, Geschwind, DH & Konopka, G 2015, 'Correspondence between Resting-State Activity and Brain Gene Expression', Neuron, vol. 88, no. 4, pp. 659-666. https://doi.org/10.1016/j.neuron.2015.10.022
Wang GZ, Belgard TG, Mao D, Chen L, Berto S, Preuss TM et al. Correspondence between Resting-State Activity and Brain Gene Expression. Neuron. 2015 Nov 18;88(4):659-666. https://doi.org/10.1016/j.neuron.2015.10.022
Wang, Guang Zhong ; Belgard, T. Grant ; Mao, Deng ; Chen, Leslie ; Berto, Stefano ; Preuss, Todd M. ; Lu, Hanzhang ; Geschwind, Daniel H. ; Konopka, Genevieve. / Correspondence between Resting-State Activity and Brain Gene Expression. In: Neuron. 2015 ; Vol. 88, No. 4. pp. 659-666.
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