Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice

Noelia V. Weisstaub, Mingming Zhou, Alena Lira, Evelyn Lambe, Javier González-Maeso, Jean Pierre Hornung, Etienna Sibille, Mark Underwood, Shigeyoshi Itohara, William T. Dauer, Mark S. Ansorge, Emanuela Morelli, J. John Mann, Miklos Toth, George Aghajanian, Stuart C. Sealfon, René Hen, Jay A. Gingrich

Research output: Contribution to journalArticlepeer-review

334 Scopus citations


Serotonin [5-hydroxytryptamine (5-HT)] neurotransmission in the central nervous system modulates depression and anxiety-related behaviors in humans and rodents, but the responsible downstream receptors remain poorly understood. We demonstrate that global disruption of 5-HT2A receptor (5HT2AR) signaling in mice reduces inhibition in conflict anxiety paradigms without affecting fear-conditioned and depression-related behaviors. Selective restoration of 5HT2AR signaling to the cortex normalized conflict anxiety behaviors. These findings indicate a specific role for cortical 5HT2AR function in the modulation of conflict anxiety, consistent with models of cortical, "top-down" influences on risk assessment.

Original languageEnglish (US)
Pages (from-to)536-540
Number of pages5
Issue number5786
StatePublished - Jul 28 2006
Externally publishedYes

ASJC Scopus subject areas

  • General


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