Creating diseases to understand what prevents them: Genetic analysis of inflammation in the gastrointestinal tract

Katharina Brandl, Bruce Beutler

Research output: Contribution to journalReview article

6 Scopus citations


Inflammatory bowel diseases (IBD), including both ulcerative colitis and Crohn's disease, are extremely variable in severity and have strong genetic components. In mice, several mutations are known to favor or inhibit intestinal inflammation. But a comprehensive picture of the pathogenesis of IBD cannot be assembled based on the limited information so far available from mouse genetic analyses, nor can human IBD be stringently ascribed to mutations known to be influential in mice. This review highlights recent progress made using mouse models created through a forward genetic approach towards the understanding of genes that normally prevent intestinal inflammation.

Original languageEnglish (US)
Pages (from-to)678-685
Number of pages8
JournalCurrent Opinion in Immunology
Issue number6
StatePublished - Dec 1 2012


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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