Crohn's Disease Is Associated With an Increased Prevalence of Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study Using Magnetic Resonance Proton Density Fat Fraction Mapping

Scott McHenry, Yeshika Sharma, Ankita Tirath, Richard Tsai, Aaron Mintz, Tyler J. Fraum, Amber Salter, Jeffrey D Browning, Avegail G. Flores, Nicholas O. Davidson, Kathryn J. Fowler, Matthew A. Ciorba, Parakkal Deepak

Research output: Contribution to journalShort survey

Abstract

Nonalcoholic fatty liver disease (NAFLD)commonly coexists with Crohn's disease (CD); however, it remains unclear if it is more prevalent than would be expected as ultrasound surveys of CD patients report a very wide range of prevalence (9%–40%). 1–3 To address this uncertainty, we performed a prospective, cross-sectional survey of NAFLD in CD patients by generating magnetic resonance proton density fat fraction (MR-PDFF)maps as compared with 2 control populations. MR-PDFF provides a quantitative, sensitive and specific (97% and 100%, respectively)radiographic surrogate for liver fat. 4

Original languageEnglish (US)
JournalClinical Gastroenterology and Hepatology
DOIs
StatePublished - Jan 1 2019

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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